Genetic markers of ADHD-related variations in intracranial volume

Marieke Klein, Raymond K. Walters, Ditte Demontis, Jason L. Stein, Derrek P. Hibar, Hieab H. Adams, Janita Bralten, Nina Roth Mota, Russell Schachar, Edmund Sonuga-Barke, Manuel Mattheisen, Benjamin M. Neale, Paul M. Thompson, Sarah E. Medland, Anders D. Børglum, Stephen V. Faraone, Alejandro Arias-Vasquez, Barbara Franke

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Objective: Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with a complex pathophysiology. Intracranial volume (ICV) and volumes of the nucleus accumbens, amygdala, caudate nucleus, hippocampus, and putamen are smaller in people with ADHD compared with healthy individuals. The authors investigated the overlap between common genetic variation associated with ADHD risk and these brain volume measures to identify underlying biological processes contributing to the disorder. Methods: The authors combined genome-wide association results from the largest available studies of ADHD (N=55,374) and brain volumes (N=11,221-24,704), using a set of complementary methods to investigate overlap at the level of global common variant genetic architecture and at the single variant level. Results: Analyses revealed a significant negative genetic correlation between ADHD and ICV (r g =20.22). Meta-analysis of single variants revealed two significant loci of interest associated with both ADHD risk and ICV; four additional loci were identified for ADHD and volumes of the amygdala, caudate nucleus, and putamen. Exploratory gene-based and gene-set analyses in the ADHD-ICV meta-analytic data showed association with variation in neurite outgrowth-related genes. Conclusions: This is the first genome-wide study to show significant genetic overlap between brain volume measures and ADHD, both on the global and the single variant level. Variants linked to smaller ICV were associated with increased ADHD risk. These findings can help us develop new hypotheses about biological mechanisms by which brain structure alterations may be involved in ADHD disease etiology.

Original languageEnglish
Pages (from-to)228-238
Number of pages11
JournalAmerican Journal of Psychiatry
Issue number3
StatePublished - Mar 2019
Externally publishedYes


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