Genetic mapping of the 21-hydroxylase locus: Estimation of small recombination frequencies

C. E. Aston; S. L. Sherman; N. E. Morton; P. W. Speiser; M. I. New

Genetic mapping of the 21-hydroxylase locus: Estimation of small recombination frequencies

C. E. Aston
, S. L. Sherman
, N. E. Morton
, P. W. Speiser
, M. I. New

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The locus for 21-hydroxylase (CA21HB) has been mapped to the interval between the HLA-B and HLA-DR loci on chromosome 6. Several methods of estimating genetic distance were used to determine whether CA21HB is closer to HLA-B or HLA-DR based on data collected on 157 families ascertained through a proband with the classical form of 21-hydroxylase deficiency (CA12Hd). The results were inconclusive but serve to highlight the limitations of present methods of estimating genetic distance when recombination frequencies are of the order of .005.

Original language	English
Pages (from-to)	304-310
Number of pages	7
Journal	American Journal of Human Genetics
Volume	43
Issue number	3
State	Published - 1988
Externally published	Yes

Cite this

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title = "Genetic mapping of the 21-hydroxylase locus: Estimation of small recombination frequencies",

abstract = "The locus for 21-hydroxylase (CA21HB) has been mapped to the interval between the HLA-B and HLA-DR loci on chromosome 6. Several methods of estimating genetic distance were used to determine whether CA21HB is closer to HLA-B or HLA-DR based on data collected on 157 families ascertained through a proband with the classical form of 21-hydroxylase deficiency (CA12Hd). The results were inconclusive but serve to highlight the limitations of present methods of estimating genetic distance when recombination frequencies are of the order of .005.",

author = "Aston, \{C. E.\} and Sherman, \{S. L.\} and Morton, \{N. E.\} and Speiser, \{P. W.\} and New, \{M. I.\}",

year = "1988",

language = "English",

volume = "43",

pages = "304--310",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "3",

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TY - JOUR

T1 - Genetic mapping of the 21-hydroxylase locus

T2 - Estimation of small recombination frequencies

AU - Aston, C. E.

AU - Sherman, S. L.

AU - Morton, N. E.

AU - Speiser, P. W.

AU - New, M. I.

PY - 1988

Y1 - 1988

N2 - The locus for 21-hydroxylase (CA21HB) has been mapped to the interval between the HLA-B and HLA-DR loci on chromosome 6. Several methods of estimating genetic distance were used to determine whether CA21HB is closer to HLA-B or HLA-DR based on data collected on 157 families ascertained through a proband with the classical form of 21-hydroxylase deficiency (CA12Hd). The results were inconclusive but serve to highlight the limitations of present methods of estimating genetic distance when recombination frequencies are of the order of .005.

AB - The locus for 21-hydroxylase (CA21HB) has been mapped to the interval between the HLA-B and HLA-DR loci on chromosome 6. Several methods of estimating genetic distance were used to determine whether CA21HB is closer to HLA-B or HLA-DR based on data collected on 157 families ascertained through a proband with the classical form of 21-hydroxylase deficiency (CA12Hd). The results were inconclusive but serve to highlight the limitations of present methods of estimating genetic distance when recombination frequencies are of the order of .005.

UR - https://www.scopus.com/pages/publications/0023766428

M3 - Article

C2 - 3137812

AN - SCOPUS:0023766428

SN - 0002-9297

VL - 43

SP - 304

EP - 310

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 3

ER -

Genetic mapping of the 21-hydroxylase locus: Estimation of small recombination frequencies

Abstract

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