Genetic linkage analysis of familial schizophrenia on chromosome 1 in a Chinese population

There are a growing number of genome wide linkage studies provided good evidence for a susceptibility locus on chromosome 1q21-q22. Brzustowicz et al. 2000 provided highly significant evidence of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22, with a maximum heterogeneity logarithm of the likelihood of lod score of 6.50 with the marker D1S1653. Hovatta et al. 1999 and Gurling et al. 1999 provided predominately suggestive findings on this region, with a maximum lod score of 3.73 and 3.82 with markers D1S2141 and D1S2891 and with a five point multipoint lod score of 3.2 with the markers D1S194-D1S196-D1S2815-D1S191 respectively. Studies in a Finnish isolated community also showed evidence for linkage in the same region (Ekelund et al., 2000).We performed a linkage study on chromosome 1 with two stage genome scan method in 32 familial schizophrenia families derived of Chinese han population.