Genetic insights into the mechanisms of Fgf signaling

J. Richard Brewer, Pierre Mazot, Philippe Soriano

Research output: Contribution to journalReview articlepeer-review

131 Scopus citations


The fibroblast growth factor (Fgf) family of ligands and receptor tyrosine kinases is required throughout embryonic and postnatal development and also regulates multiple homeostatic functions in the adult. Aberrant Fgf signaling causes many congenital disorders and underlies multiple forms of cancer. Understanding the mechanisms that govern Fgf signaling is therefore important to appreciate many aspects of Fgf biology and disease. Here we review the mechanisms of Fgf signaling by focusing on genetic strategies that enable in vivo analysis. These studies support an important role for Erk1/2 as a mediator of Fgf signaling in many biological processes but have also provided strong evidence for additional signaling pathways in transmitting Fgf signaling in vivo.

Original languageEnglish
Pages (from-to)751-771
Number of pages21
JournalGenes and Development
Issue number7
StatePublished - 1 Apr 2016


  • Erk1/2
  • Fgfr
  • Fibroblast growth factor
  • Receptor tyrosine kinase
  • Signaling


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