@inproceedings{f721e4551c51479a8706e392e04a39a3,
title = "Genetic influences on sulcal patterns of the brain",
abstract = "We present a shape-space approach for analyzing genetic influences on the shapes of the sulcal folding patterns on the cortex. Sulci are represented as continuously parameterized functions in a shape space, and shape differences between sulci are obtained via geodesics between them. The resulting statistical shape analysis framework is used not only to construct populations averages, but also used to compute meaningful correlations within and across groups of sulcal shapes. More importantly, we present a new algorithm that extends the traditional Euclidean estimate of the intra-class correlation to the geometric shape space, thereby allowing us to study heritability of sulcal shape traits for a population of 193 twin pairs. This new methodology reveals strong genetic influences on the sulcal geometry of the cortex.",
keywords = "brain imaging, genetics, heritability, shape analysis, sulcal curves",
author = "Joshi, \{S. H.\} and Joshi, \{A. A.\} and B. Gutman and Toga, \{A. W.\} and K. McMahon and \{De Zubicaray\}, G. and N. Martin and Wright, \{M. J.\} and Thompson, \{P. M.\}",
year = "2012",
doi = "10.1109/ISBI.2012.6235572",
language = "English",
isbn = "9781457718588",
series = "Proceedings - International Symposium on Biomedical Imaging",
publisher = "IEEE Computer Society",
pages = "414--417",
booktitle = "2012 9th IEEE International Symposium on Biomedical Imaging",
address = "United States",
note = "9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 ; Conference date: 02-05-2012 Through 05-05-2012",
}