TY - JOUR
T1 - Genetic footprints of assortative mating in the Japanese population
AU - The BioBank Japan Project
AU - Yamamoto, Kenichi
AU - Sonehara, Kyuto
AU - Namba, Shinichi
AU - Konuma, Takahiro
AU - Masuko, Hironori
AU - Miyawaki, Satoru
AU - Kamatani, Yoichiro
AU - Hizawa, Nobuyuki
AU - Ozono, Keiichi
AU - Yengo, Loic
AU - Okada, Yukinori
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2023/1
Y1 - 2023/1
N2 - Assortative mating (AM) is a pattern characterized by phenotypic similarities between mating partners. Detecting the evidence of AM has been challenging due to the lack of large-scale datasets that include phenotypic data on both partners, especially in populations of non-European ancestries. Gametic phase disequilibrium between trait-associated alleles is a signature of parental AM on a polygenic trait, which can be detected even without partner data. Here, using polygenic scores for 81 traits in the Japanese population using BioBank Japan Project genome-wide association studies data (n = 172,270), we found evidence of AM on the liability to type 2 diabetes and coronary artery disease, as well as on dietary habits. In cross-population comparison using United Kingdom Biobank data (n = 337,139) we found shared but heterogeneous impacts of AM between populations.
AB - Assortative mating (AM) is a pattern characterized by phenotypic similarities between mating partners. Detecting the evidence of AM has been challenging due to the lack of large-scale datasets that include phenotypic data on both partners, especially in populations of non-European ancestries. Gametic phase disequilibrium between trait-associated alleles is a signature of parental AM on a polygenic trait, which can be detected even without partner data. Here, using polygenic scores for 81 traits in the Japanese population using BioBank Japan Project genome-wide association studies data (n = 172,270), we found evidence of AM on the liability to type 2 diabetes and coronary artery disease, as well as on dietary habits. In cross-population comparison using United Kingdom Biobank data (n = 337,139) we found shared but heterogeneous impacts of AM between populations.
UR - http://www.scopus.com/inward/record.url?scp=85138516211&partnerID=8YFLogxK
U2 - 10.1038/s41562-022-01438-z
DO - 10.1038/s41562-022-01438-z
M3 - Article
AN - SCOPUS:85138516211
SN - 2397-3374
VL - 7
SP - 65
EP - 73
JO - Nature Human Behaviour
JF - Nature Human Behaviour
IS - 1
ER -