Genetic footprints of assortative mating in the Japanese population

The BioBank Japan Project

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Assortative mating (AM) is a pattern characterized by phenotypic similarities between mating partners. Detecting the evidence of AM has been challenging due to the lack of large-scale datasets that include phenotypic data on both partners, especially in populations of non-European ancestries. Gametic phase disequilibrium between trait-associated alleles is a signature of parental AM on a polygenic trait, which can be detected even without partner data. Here, using polygenic scores for 81 traits in the Japanese population using BioBank Japan Project genome-wide association studies data (n = 172,270), we found evidence of AM on the liability to type 2 diabetes and coronary artery disease, as well as on dietary habits. In cross-population comparison using United Kingdom Biobank data (n = 337,139) we found shared but heterogeneous impacts of AM between populations.

Original languageEnglish
Pages (from-to)65-73
Number of pages9
JournalNature Human Behaviour
Volume7
Issue number1
DOIs
StatePublished - Jan 2023
Externally publishedYes

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