Genetic correlations between subcortical brain volumes and psychiatric disorders

Kazutaka Ohi, Takamitsu Shimada, Yuzuru Kataoka, Toshiki Yasuyama, Yasuhiro Kawasaki, Toshiki Shioiri, Paul M. Thompson

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Psychiatric disorders as well as subcortical brain volumes are highly heritable. Large-scale genome-wide association studies (GWASs) for these traits have been performed. We investigated the genetic correlations between five psychiatric disorders and the seven subcortical brain volumes and the intracranial volume from large-scale GWASs by linkage disequilibrium score regression. We revealed weak overlaps between the genetic variants associated with psychiatric disorders and subcortical brain and intracranial volumes, such as in schizophrenia and the hippocampus and bipolar disorder and the accumbens. We confirmed shared aetiology and polygenic architecture across the psychiatric disorders and the specific subcortical brain and intracranial volume.

Original languageEnglish
Pages (from-to)280-283
Number of pages4
JournalBritish Journal of Psychiatry
Volume216
Issue number5
DOIs
StatePublished - 1 May 2020
Externally publishedYes

Keywords

  • Genetic correlation
  • Genome-wide association study
  • Linkage disequilibrium score regression
  • Psychiatric disorder
  • Subcortical volume

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