Genetic control of "natural" killer lymphocytes in the mouse

Gyözö G. Petrányi; Rolf Kiessling; George Klein

doi:10.1007/BF01572274

Genetic control of "natural" killer lymphocytes in the mouse

Gyözö G. Petrányi, Rolf Kiessling, George Klein

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87 Scopus citations

Abstract

Spleens from normal young mice contain lymphocytes that can kill certain in vitro grown Moloney lymphoma lines in a⁵¹Cr-release cytotoxicity test. A lymphoid cell without detectable T- or B-cell markers was previously shown to be responsible. Killing activity shows a marked dependence on the genotype of the donor mouse. When tested against a YAC line of strain A origin maintained in vitro spleens of A, A.CA, and A.SW mice had low activity, whereas CBA, C3H, C57L, and C57Bl spleens were highly active. In semisyngeneic F₁ crosses with strain A as one parent, reactivity resembled the opposite parental strain. Thus, (A×CBA)F₁, (A×C3H)F₁, (A×C57L)F₁, and (A×C57Bl)F₁ were reactive, whereas A×A.CA showed no significant activity. Analysis of the reactivity in (A×C57Bl)F₁×A backcross mice suggests that multiple genes are involved. Preliminary linkage analysis suggests at least one H-2 linked factor. Another gene appears to be linked to the B (black) locus.

Original language	English
Pages (from-to)	53-61
Number of pages	9
Journal	Immunogenetics
Volume	2
Issue number	1
DOIs	https://doi.org/10.1007/BF01572274
State	Published - Dec 1975
Externally published	Yes

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title = "Genetic control of {"}natural{"} killer lymphocytes in the mouse",

abstract = "Spleens from normal young mice contain lymphocytes that can kill certain in vitro grown Moloney lymphoma lines in a51Cr-release cytotoxicity test. A lymphoid cell without detectable T- or B-cell markers was previously shown to be responsible. Killing activity shows a marked dependence on the genotype of the donor mouse. When tested against a YAC line of strain A origin maintained in vitro spleens of A, A.CA, and A.SW mice had low activity, whereas CBA, C3H, C57L, and C57Bl spleens were highly active. In semisyngeneic F1 crosses with strain A as one parent, reactivity resembled the opposite parental strain. Thus, (A×CBA)F1, (A×C3H)F1, (A×C57L)F1, and (A×C57Bl)F1 were reactive, whereas A×A.CA showed no significant activity. Analysis of the reactivity in (A×C57Bl)F1×A backcross mice suggests that multiple genes are involved. Preliminary linkage analysis suggests at least one H-2 linked factor. Another gene appears to be linked to the B (black) locus.",

author = "Petr{\'a}nyi, {Gy{\"o}z{\"o} G.} and Rolf Kiessling and George Klein",

year = "1975",

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doi = "10.1007/BF01572274",

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AU - Petrányi, Gyözö G.

AU - Kiessling, Rolf

AU - Klein, George

PY - 1975/12

Y1 - 1975/12

N2 - Spleens from normal young mice contain lymphocytes that can kill certain in vitro grown Moloney lymphoma lines in a51Cr-release cytotoxicity test. A lymphoid cell without detectable T- or B-cell markers was previously shown to be responsible. Killing activity shows a marked dependence on the genotype of the donor mouse. When tested against a YAC line of strain A origin maintained in vitro spleens of A, A.CA, and A.SW mice had low activity, whereas CBA, C3H, C57L, and C57Bl spleens were highly active. In semisyngeneic F1 crosses with strain A as one parent, reactivity resembled the opposite parental strain. Thus, (A×CBA)F1, (A×C3H)F1, (A×C57L)F1, and (A×C57Bl)F1 were reactive, whereas A×A.CA showed no significant activity. Analysis of the reactivity in (A×C57Bl)F1×A backcross mice suggests that multiple genes are involved. Preliminary linkage analysis suggests at least one H-2 linked factor. Another gene appears to be linked to the B (black) locus.

AB - Spleens from normal young mice contain lymphocytes that can kill certain in vitro grown Moloney lymphoma lines in a51Cr-release cytotoxicity test. A lymphoid cell without detectable T- or B-cell markers was previously shown to be responsible. Killing activity shows a marked dependence on the genotype of the donor mouse. When tested against a YAC line of strain A origin maintained in vitro spleens of A, A.CA, and A.SW mice had low activity, whereas CBA, C3H, C57L, and C57Bl spleens were highly active. In semisyngeneic F1 crosses with strain A as one parent, reactivity resembled the opposite parental strain. Thus, (A×CBA)F1, (A×C3H)F1, (A×C57L)F1, and (A×C57Bl)F1 were reactive, whereas A×A.CA showed no significant activity. Analysis of the reactivity in (A×C57Bl)F1×A backcross mice suggests that multiple genes are involved. Preliminary linkage analysis suggests at least one H-2 linked factor. Another gene appears to be linked to the B (black) locus.

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Genetic control of "natural" killer lymphocytes in the mouse

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