Genetic composition of a high-yielding influenza A virus recombinant: A vaccine strain against "swine" influenza

Peter Palese; Mary B. Ritchey; Jerome L. Schulman; Edwin D. Kilbourne

doi:10.1126/science.968486

Genetic composition of a high-yielding influenza A virus recombinant: A vaccine strain against "swine" influenza

Peter Palese
, Mary B. Ritchey
, Jerome L. Schulman
, Edwin D. Kilbourne

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Analysis of the RNA migration pattern of a high-yielding influenza virus recombinant, X-53, used in vaccine production, reveals that only the two genes coding for hemagglutinin and neuraminidase antigens were derived from the "swine" influenza virus parent, A/New Jersey/1176, while six were acquired from the A/PR/8/34 (HON1) parent, donor of the high yield characteristic.

Original language	English
Pages (from-to)	334-335
Number of pages	2
Journal	Science
Volume	194
Issue number	4262
DOIs	https://doi.org/10.1126/science.968486
State	Published - 1976
Externally published	Yes

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abstract = "Analysis of the RNA migration pattern of a high-yielding influenza virus recombinant, X-53, used in vaccine production, reveals that only the two genes coding for hemagglutinin and neuraminidase antigens were derived from the {"}swine{"} influenza virus parent, A/New Jersey/1176, while six were acquired from the A/PR/8/34 (HON1) parent, donor of the high yield characteristic.",

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AU - Kilbourne, Edwin D.

PY - 1976

Y1 - 1976

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AB - Analysis of the RNA migration pattern of a high-yielding influenza virus recombinant, X-53, used in vaccine production, reveals that only the two genes coding for hemagglutinin and neuraminidase antigens were derived from the "swine" influenza virus parent, A/New Jersey/1176, while six were acquired from the A/PR/8/34 (HON1) parent, donor of the high yield characteristic.

UR - https://www.scopus.com/pages/publications/0017202349

U2 - 10.1126/science.968486

DO - 10.1126/science.968486

M3 - Article

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AN - SCOPUS:0017202349

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VL - 194

SP - 334

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JO - Science

JF - Science

IS - 4262

ER -

Genetic composition of a high-yielding influenza A virus recombinant: A vaccine strain against "swine" influenza

Abstract

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