Genetic characterization of a novel familial dementia

J. Brown; S. Smith; A. Brun; J. Collinge; S. Gydesen; J. Hardy; M. Mullan; A. Goate

doi:10.1111/j.1749-6632.1991.tb00213.x

Genetic characterization of a novel familial dementia

J. Brown, S. Smith, A. Brun, J. Collinge, S. Gydesen, J. Hardy, M. Mullan, A. Goate

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Clinical and neuropathologic findings from a Danish family in which a dementing illness is segregating as an apparent autosomal dominant disorder were previously described (Gydesen et al. 1987). We present here genetic findings from this family in which linkage analysis has excluded Huntington's disease and chromosome 21-encoded Alzheimer's disease. None of the known prion mutations has been detected in affected individuals from this family. However, linkage analysis with the prion gene has been uninformative. This family probably represents a novel genetic dementia.

Original language	English
Pages (from-to)	181-183
Number of pages	3
Journal	Annals of the New York Academy of Sciences
Volume	640
DOIs	https://doi.org/10.1111/j.1749-6632.1991.tb00213.x
State	Published - 1991
Externally published	Yes

Access to Document

10.1111/j.1749-6632.1991.tb00213.x

Cite this

@article{8ed3055f65c34910a686b04fee018d75,

title = "Genetic characterization of a novel familial dementia",

abstract = "Clinical and neuropathologic findings from a Danish family in which a dementing illness is segregating as an apparent autosomal dominant disorder were previously described (Gydesen et al. 1987). We present here genetic findings from this family in which linkage analysis has excluded Huntington's disease and chromosome 21-encoded Alzheimer's disease. None of the known prion mutations has been detected in affected individuals from this family. However, linkage analysis with the prion gene has been uninformative. This family probably represents a novel genetic dementia.",

author = "J. Brown and S. Smith and A. Brun and J. Collinge and S. Gydesen and J. Hardy and M. Mullan and A. Goate",

year = "1991",

doi = "10.1111/j.1749-6632.1991.tb00213.x",

language = "English",

volume = "640",

pages = "181--183",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "New York Academy of Sciences",

}

TY - JOUR

T1 - Genetic characterization of a novel familial dementia

AU - Brown, J.

AU - Smith, S.

AU - Brun, A.

AU - Collinge, J.

AU - Gydesen, S.

AU - Hardy, J.

AU - Mullan, M.

AU - Goate, A.

PY - 1991

Y1 - 1991

N2 - Clinical and neuropathologic findings from a Danish family in which a dementing illness is segregating as an apparent autosomal dominant disorder were previously described (Gydesen et al. 1987). We present here genetic findings from this family in which linkage analysis has excluded Huntington's disease and chromosome 21-encoded Alzheimer's disease. None of the known prion mutations has been detected in affected individuals from this family. However, linkage analysis with the prion gene has been uninformative. This family probably represents a novel genetic dementia.

AB - Clinical and neuropathologic findings from a Danish family in which a dementing illness is segregating as an apparent autosomal dominant disorder were previously described (Gydesen et al. 1987). We present here genetic findings from this family in which linkage analysis has excluded Huntington's disease and chromosome 21-encoded Alzheimer's disease. None of the known prion mutations has been detected in affected individuals from this family. However, linkage analysis with the prion gene has been uninformative. This family probably represents a novel genetic dementia.

UR - http://www.scopus.com/inward/record.url?scp=0026378668&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.1991.tb00213.x

DO - 10.1111/j.1749-6632.1991.tb00213.x

M3 - Article

C2 - 1776737

AN - SCOPUS:0026378668

SN - 0077-8923

VL - 640

SP - 181

EP - 183

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Genetic characterization of a novel familial dementia

Abstract

Access to Document

Fingerprint

Cite this