Genetic characterization of a novel familial dementia

J. Brown; S. Smith; A. Brun; J. Collinge; S. Gydesen; J. Hardy; M. Mullan; A. Goate

doi:10.1111/j.1749-6632.1991.tb00213.x

Genetic characterization of a novel familial dementia

J. Brown, S. Smith, A. Brun, J. Collinge, S. Gydesen, J. Hardy, M. Mullan, A. Goate

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Clinical and neuropathologic findings from a Danish family in which a dementing illness is segregating as an apparent autosomal dominant disorder were previously described (Gydesen et al. 1987). We present here genetic findings from this family in which linkage analysis has excluded Huntington's disease and chromosome 21-encoded Alzheimer's disease. None of the known prion mutations has been detected in affected individuals from this family. However, linkage analysis with the prion gene has been uninformative. This family probably represents a novel genetic dementia.

Original language	English
Pages (from-to)	181-183
Number of pages	3
Journal	Annals of the New York Academy of Sciences
Volume	640
DOIs	https://doi.org/10.1111/j.1749-6632.1991.tb00213.x
State	Published - 1991
Externally published	Yes

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abstract = "Clinical and neuropathologic findings from a Danish family in which a dementing illness is segregating as an apparent autosomal dominant disorder were previously described (Gydesen et al. 1987). We present here genetic findings from this family in which linkage analysis has excluded Huntington's disease and chromosome 21-encoded Alzheimer's disease. None of the known prion mutations has been detected in affected individuals from this family. However, linkage analysis with the prion gene has been uninformative. This family probably represents a novel genetic dementia.",

author = "J. Brown and S. Smith and A. Brun and J. Collinge and S. Gydesen and J. Hardy and M. Mullan and A. Goate",

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doi = "10.1111/j.1749-6632.1991.tb00213.x",

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AU - Brown, J.

AU - Smith, S.

AU - Brun, A.

AU - Collinge, J.

AU - Gydesen, S.

AU - Hardy, J.

AU - Mullan, M.

AU - Goate, A.

PY - 1991

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AB - Clinical and neuropathologic findings from a Danish family in which a dementing illness is segregating as an apparent autosomal dominant disorder were previously described (Gydesen et al. 1987). We present here genetic findings from this family in which linkage analysis has excluded Huntington's disease and chromosome 21-encoded Alzheimer's disease. None of the known prion mutations has been detected in affected individuals from this family. However, linkage analysis with the prion gene has been uninformative. This family probably represents a novel genetic dementia.

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U2 - 10.1111/j.1749-6632.1991.tb00213.x

DO - 10.1111/j.1749-6632.1991.tb00213.x

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JO - Annals of The Lyceum of Natural History of New York

JF - Annals of The Lyceum of Natural History of New York

SN - 0890-6564

ER -

Genetic characterization of a novel familial dementia

Abstract

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