Genetic and Environmental Risk Factors for Pediatric Multiple Sclerosis

Ilena C. George, Naila Makhani

Research output: Contribution to journalReview articlepeer-review

Abstract

Both genetic and environmental risk factors may contribute to risk of multiple sclerosis (MS) in children. Genetic risk factors include the presence of the human leukocyte antigen (HLA)-DRB1∗1501 allele and other non-HLA single nucleotide polymorphisms. Environmental risk factors include parental smoking, low serum vitamin D levels, and prior exposure to Epstein-Barr virus. Some of these risk factors not only confer increased susceptibility to MS but may also alter the course of the disease. How different risk factors interact is a growing area of research. In this review, we examine the current literature regarding the genetic and environmental risk factors for MS in children.

Original languageEnglish
Pages (from-to)141-147
Number of pages7
JournalJournal of Pediatric Neurology
Volume16
Issue number3
DOIs
StatePublished - 1 Jun 2018
Externally publishedYes

Keywords

  • children
  • environmental
  • genetic
  • multiple sclerosis

Fingerprint

Dive into the research topics of 'Genetic and Environmental Risk Factors for Pediatric Multiple Sclerosis'. Together they form a unique fingerprint.

Cite this