Genetic analysis of structural brain connectivity using DICCCOL models of diffusion MRI in 522 twins

Dajiang Zhu, Liang Zhan, Joshua Faskowitz, Madelaine Daianu, Neda Jahanshad, Greig I. De Zubicaray, Katie L. McMahon, Nicholas G. Martin, Margaret J. Wright, Paul M. Thompson

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Genetic and environmental factors affect white matter connectivity in the normal brain, and they also influence diseases in which brain connectivity is altered. Little is known about genetic influences on brain connectivity, despite wide variations in the brain's neural pathways. Here we applied the 'DICCCOL' framework to analyze structural connectivity, in 261 twin pairs (522 participants, mean age: 21.8 y ± 2.7SD). We encoded connectivity patterns by projecting the white matter (WM) bundles of all 'DICCCOLs' as a tracemap (TM). Next we fitted an A/C/E structural equation model to estimate additive genetic (A), common environmental (C), and unique environmental/error (E) components of the observed variations in brain connectivity. We found 44 'heritable DICCCOLs' whose connectivity was genetically influenced (α2>1%); half of them showed significant heritability (α2>20%). Our analysis of genetic influences on WM structural connectivity suggests high heritability for some WM projection patterns, yielding new targets for genome-wide association studies.

Original languageEnglish
Title of host publication2015 IEEE 12th International Symposium on Biomedical Imaging, ISBI 2015
PublisherIEEE Computer Society
Pages1167-1171
Number of pages5
ISBN (Electronic)9781479923748
DOIs
StatePublished - 21 Jul 2015
Externally publishedYes
Event12th IEEE International Symposium on Biomedical Imaging, ISBI 2015 - Brooklyn, United States
Duration: 16 Apr 201519 Apr 2015

Publication series

NameProceedings - International Symposium on Biomedical Imaging
Volume2015-July
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Conference

Conference12th IEEE International Symposium on Biomedical Imaging, ISBI 2015
Country/TerritoryUnited States
CityBrooklyn
Period16/04/1519/04/15

Keywords

  • DICCCOL
  • heritability

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