Genes influence the amplitude and timing of brain hemodynamic responses

Zuyao Y. Shan; Anna A.E. Vinkhuyzen; Paul M. Thompson; Katie L. McMahon; Gabriëlla A.M. Blokland; Greig I. de Zubicaray; Vince Calhoun; Nicholas G. Martin; Peter M. Visscher; Margaret J. Wright; David C. Reutens

doi:10.1016/j.neuroimage.2015.09.016

Genes influence the amplitude and timing of brain hemodynamic responses

Zuyao Y. Shan, Anna A.E. Vinkhuyzen, Paul M. Thompson, Katie L. McMahon, Gabriëlla A.M. Blokland, Greig I. de Zubicaray, Vince Calhoun, Nicholas G. Martin, Peter M. Visscher, Margaret J. Wright, David C. Reutens

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

In functional magnetic resonance imaging (fMRI), the hemodynamic response function (HRF) reflects regulation of regional cerebral blood flow in response to neuronal activation. The HRF varies significantly between individuals. This study investigated the genetic contribution to individual variation in HRF using fMRI data from 125 monozygotic (MZ) and 149 dizygotic (DZ) twin pairs. The resemblance in amplitude, latency, and duration of the HRF in six regions in the frontal and parietal lobes was compared between MZ and DZ twin pairs. Heritability was estimated using an ACE (Additive genetic, Common environmental, and unique Environmental factors) model. The genetic influence on the temporal profile and amplitude of HRF was moderate to strong (24%-51%). The HRF may be used in the genetic analysis of diseases with a cerebrovascular etiology.

Original language	English
Pages (from-to)	663-671
Number of pages	9
Journal	NeuroImage
Volume	124
DOIs	https://doi.org/10.1016/j.neuroimage.2015.09.016
State	Published - 1 Jan 2016
Externally published	Yes

Keywords

Hemodynamic response function (HRF)
Heritability
Neurovascular coupling
Twin study

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10.1016/j.neuroimage.2015.09.016

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title = "Genes influence the amplitude and timing of brain hemodynamic responses",

abstract = "In functional magnetic resonance imaging (fMRI), the hemodynamic response function (HRF) reflects regulation of regional cerebral blood flow in response to neuronal activation. The HRF varies significantly between individuals. This study investigated the genetic contribution to individual variation in HRF using fMRI data from 125 monozygotic (MZ) and 149 dizygotic (DZ) twin pairs. The resemblance in amplitude, latency, and duration of the HRF in six regions in the frontal and parietal lobes was compared between MZ and DZ twin pairs. Heritability was estimated using an ACE (Additive genetic, Common environmental, and unique Environmental factors) model. The genetic influence on the temporal profile and amplitude of HRF was moderate to strong (24%-51%). The HRF may be used in the genetic analysis of diseases with a cerebrovascular etiology.",

keywords = "Hemodynamic response function (HRF), Heritability, Neurovascular coupling, Twin study",

author = "Shan, {Zuyao Y.} and Vinkhuyzen, {Anna A.E.} and Thompson, {Paul M.} and McMahon, {Katie L.} and Blokland, {Gabri{\"e}lla A.M.} and {de Zubicaray}, {Greig I.} and Vince Calhoun and Martin, {Nicholas G.} and Visscher, {Peter M.} and Wright, {Margaret J.} and Reutens, {David C.}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2016",

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doi = "10.1016/j.neuroimage.2015.09.016",

language = "English",

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AU - Shan, Zuyao Y.

AU - Vinkhuyzen, Anna A.E.

AU - Thompson, Paul M.

AU - McMahon, Katie L.

AU - Blokland, Gabriëlla A.M.

AU - de Zubicaray, Greig I.

AU - Calhoun, Vince

AU - Martin, Nicholas G.

AU - Visscher, Peter M.

AU - Wright, Margaret J.

AU - Reutens, David C.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - In functional magnetic resonance imaging (fMRI), the hemodynamic response function (HRF) reflects regulation of regional cerebral blood flow in response to neuronal activation. The HRF varies significantly between individuals. This study investigated the genetic contribution to individual variation in HRF using fMRI data from 125 monozygotic (MZ) and 149 dizygotic (DZ) twin pairs. The resemblance in amplitude, latency, and duration of the HRF in six regions in the frontal and parietal lobes was compared between MZ and DZ twin pairs. Heritability was estimated using an ACE (Additive genetic, Common environmental, and unique Environmental factors) model. The genetic influence on the temporal profile and amplitude of HRF was moderate to strong (24%-51%). The HRF may be used in the genetic analysis of diseases with a cerebrovascular etiology.

AB - In functional magnetic resonance imaging (fMRI), the hemodynamic response function (HRF) reflects regulation of regional cerebral blood flow in response to neuronal activation. The HRF varies significantly between individuals. This study investigated the genetic contribution to individual variation in HRF using fMRI data from 125 monozygotic (MZ) and 149 dizygotic (DZ) twin pairs. The resemblance in amplitude, latency, and duration of the HRF in six regions in the frontal and parietal lobes was compared between MZ and DZ twin pairs. Heritability was estimated using an ACE (Additive genetic, Common environmental, and unique Environmental factors) model. The genetic influence on the temporal profile and amplitude of HRF was moderate to strong (24%-51%). The HRF may be used in the genetic analysis of diseases with a cerebrovascular etiology.

KW - Hemodynamic response function (HRF)

KW - Heritability

KW - Neurovascular coupling

KW - Twin study

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SP - 663

EP - 671

JO - NeuroImage

JF - NeuroImage

ER -

Genes influence the amplitude and timing of brain hemodynamic responses

Abstract

Keywords

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