Generation of discriminatory PL against HLA-D antigens not detected by serology

Karen S. Zier; Bernd Gansbacher

doi:10.1016/0198-8859(81)90043-4

Generation of discriminatory PL against HLA-D antigens not detected by serology

Karen S. Zier
, Bernd Gansbacher

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A family was studied in which the father and the mother were both homozygous for the HLA-DR antigens. All children responded to the parents in MLC, even though each had a copy of the parental DR antigen, implying that they recognized a difference. When the father or the mother was sensitized in PLT against any child, all siblings could restimulate equally well. However, by sensitizing a family member with one copy of the DR phenotype against another family member with the alternate form of the phenotype, discriminatory PL could be produced. This may help define the subtypic specificities of PL antigens.

Original language	English
Pages (from-to)	57-65
Number of pages	9
Journal	Human Immunology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/0198-8859(81)90043-4
State	Published - Aug 1981
Externally published	Yes

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title = "Generation of discriminatory PL against HLA-D antigens not detected by serology",

abstract = "A family was studied in which the father and the mother were both homozygous for the HLA-DR antigens. All children responded to the parents in MLC, even though each had a copy of the parental DR antigen, implying that they recognized a difference. When the father or the mother was sensitized in PLT against any child, all siblings could restimulate equally well. However, by sensitizing a family member with one copy of the DR phenotype against another family member with the alternate form of the phenotype, discriminatory PL could be produced. This may help define the subtypic specificities of PL antigens.",

author = "Zier, \{Karen S.\} and Bernd Gansbacher",

note = "Funding Information: ACKNOWLEDGMENTS This work was supported by grants from SFl3 and DFG AL 92-11-12.",

year = "1981",

month = aug,

doi = "10.1016/0198-8859(81)90043-4",

language = "English",

volume = "3",

pages = "57--65",

journal = "Human Immunology",

issn = "0198-8859",

publisher = "Elsevier Inc.",

number = "1",

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T1 - Generation of discriminatory PL against HLA-D antigens not detected by serology

AU - Zier, Karen S.

AU - Gansbacher, Bernd

N1 - Funding Information: ACKNOWLEDGMENTS This work was supported by grants from SFl3 and DFG AL 92-11-12.

PY - 1981/8

Y1 - 1981/8

N2 - A family was studied in which the father and the mother were both homozygous for the HLA-DR antigens. All children responded to the parents in MLC, even though each had a copy of the parental DR antigen, implying that they recognized a difference. When the father or the mother was sensitized in PLT against any child, all siblings could restimulate equally well. However, by sensitizing a family member with one copy of the DR phenotype against another family member with the alternate form of the phenotype, discriminatory PL could be produced. This may help define the subtypic specificities of PL antigens.

AB - A family was studied in which the father and the mother were both homozygous for the HLA-DR antigens. All children responded to the parents in MLC, even though each had a copy of the parental DR antigen, implying that they recognized a difference. When the father or the mother was sensitized in PLT against any child, all siblings could restimulate equally well. However, by sensitizing a family member with one copy of the DR phenotype against another family member with the alternate form of the phenotype, discriminatory PL could be produced. This may help define the subtypic specificities of PL antigens.

UR - https://www.scopus.com/pages/publications/0019825515

U2 - 10.1016/0198-8859(81)90043-4

DO - 10.1016/0198-8859(81)90043-4

M3 - Article

C2 - 6168622

AN - SCOPUS:0019825515

SN - 0198-8859

VL - 3

SP - 57

EP - 65

JO - Human Immunology

JF - Human Immunology

IS - 1

ER -

Generation of discriminatory PL against HLA-D antigens not detected by serology

Abstract

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