Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation

Dominantly Inherited Alzheimer Network (DIAN)

doi:10.1016/j.scr.2024.103495

Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation

Dominantly Inherited Alzheimer Network (DIAN)

Research output: Contribution to journal › Article › peer-review

Abstract

We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer's disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem cell morphology, expression of pluripotency markers, and maintains a normal karyotype.

Original language	English
Article number	103495
Journal	Stem Cell Research
Volume	79
DOIs	https://doi.org/10.1016/j.scr.2024.103495
State	Published - Sep 2024

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10.1016/j.scr.2024.103495

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@article{b1ae0aae41d94273b3e2302c6cfae80a,

title = "Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation",

abstract = "We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer's disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem cell morphology, expression of pluripotency markers, and maintains a normal karyotype.",

author = "{Dominantly Inherited Alzheimer Network (DIAN)} and Dami{\'a}n Hern{\'a}ndez and {Morgan Schlicht}, Stephanie and {Elli Clarke}, Jordan and Maciej Daniszewski and Karch, {Celeste M.} and Sarah Adams and Ricardo Allegri and Aki Araki and Nicolas Barthelemy and Randall Bateman and Jacob Bechara and Tammie Benzinger and Sarah Berman and Courtney Bodge and Sus Brandon and {(Bill) Brooks}, William and Jared Brosch and Jill Buck and Virginia Buckles and Kathleen Carter and Lisa Cash and Charlie Chen and Jasmeer Chhatwal and {Chrem Mendez}, Patricio and Jasmin Chua and Helena Chui and Laura Courtney and Carlos Cruchaga and Day, {Gregory S.} and Chrismary DeLaCruz and Darcy Denner and Anna Diffenbacher and Aylin Dincer and Tamara Donahue and Jane Douglas and Duc Duong and Noelia Egido and Bianca Esposito and Anne Fagan and Marty Farlow and Becca Feldman and Colleen Fitzpatrick and Shaney Flores and Nick Fox and Erin Franklin and Nelly Joseph-Mathurin and Hisako Fujii and Alison Goate and Alan Renton and Goate, {Alison M.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",

year = "2024",

month = sep,

doi = "10.1016/j.scr.2024.103495",

language = "English",

volume = "79",

journal = "Stem Cell Research",

issn = "1873-5061",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation

AU - Dominantly Inherited Alzheimer Network (DIAN)

AU - Hernández, Damián

AU - Morgan Schlicht, Stephanie

AU - Elli Clarke, Jordan

AU - Daniszewski, Maciej

AU - Karch, Celeste M.

AU - Adams, Sarah

AU - Allegri, Ricardo

AU - Araki, Aki

AU - Barthelemy, Nicolas

AU - Bateman, Randall

AU - Bechara, Jacob

AU - Benzinger, Tammie

AU - Berman, Sarah

AU - Bodge, Courtney

AU - Brandon, Sus

AU - (Bill) Brooks, William

AU - Brosch, Jared

AU - Buck, Jill

AU - Buckles, Virginia

AU - Carter, Kathleen

AU - Cash, Lisa

AU - Chen, Charlie

AU - Chhatwal, Jasmeer

AU - Chrem Mendez, Patricio

AU - Chua, Jasmin

AU - Chui, Helena

AU - Courtney, Laura

AU - Cruchaga, Carlos

AU - Day, Gregory S.

AU - DeLaCruz, Chrismary

AU - Denner, Darcy

AU - Diffenbacher, Anna

AU - Dincer, Aylin

AU - Donahue, Tamara

AU - Douglas, Jane

AU - Duong, Duc

AU - Egido, Noelia

AU - Esposito, Bianca

AU - Fagan, Anne

AU - Farlow, Marty

AU - Feldman, Becca

AU - Fitzpatrick, Colleen

AU - Flores, Shaney

AU - Fox, Nick

AU - Franklin, Erin

AU - Joseph-Mathurin, Nelly

AU - Fujii, Hisako

AU - Goate, Alison

AU - Renton, Alan

AU - Goate, Alison M.

PY - 2024/9

Y1 - 2024/9

N2 - We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer's disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem cell morphology, expression of pluripotency markers, and maintains a normal karyotype.

AB - We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer's disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem cell morphology, expression of pluripotency markers, and maintains a normal karyotype.

UR - http://www.scopus.com/inward/record.url?scp=85199722897&partnerID=8YFLogxK

U2 - 10.1016/j.scr.2024.103495

DO - 10.1016/j.scr.2024.103495

M3 - Article

AN - SCOPUS:85199722897

SN - 1873-5061

VL - 79

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 103495

ER -

Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation

Abstract

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