@inproceedings{014caf74e4d24721b9de333dbdf1ef23,
title = "Generation of 3-D glioblastoma-vascular niche using 3-D bioprinting",
abstract = "Glioblastoma multiforme (GBM), a malignant brain tumor, frequently exploit microvessels as guides for migration. Understanding cell-cell interaction between vascular cells and GBM cells may suggest a new therapeutic direction. We developed physiological 3-D glioma-vascular niche model to investigate this cell-cell interaction using 3-D bioprinting technology. In the model, patient-derived GBM cell cluster was closely located to fluidic vessel. The influence of microenvironmental factors (matrix composition) has been tested in order to provide better control on 3-D cell behavior in future research. The 3D vascular niche platform can be adapted to other biological systems and will be used as a valuable tool to model cell-cell interactions and to control microenvironment in other systems.",
keywords = "3D bio-printing, cancer-vascular niche, glioblastoma, glioblastoma multiforme, glioma, hydrogel, tumor invasion, vascular niche",
author = "Lee, {Vivian K.} and Guohao Dai and Hongyan Zou and Yoo, {Seung Schik}",
note = "Publisher Copyright: {\textcopyright} 2015 IEEE.; 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 ; Conference date: 17-04-2015 Through 19-04-2015",
year = "2015",
month = jun,
day = "2",
doi = "10.1109/NEBEC.2015.7117111",
language = "English",
series = "2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
booktitle = "2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015",
address = "United States",
}