Generation of 3-D glioblastoma-vascular niche using 3-D bioprinting

Vivian K. Lee, Guohao Dai, Hongyan Zou, Seung Schik Yoo

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

27 Scopus citations

Abstract

Glioblastoma multiforme (GBM), a malignant brain tumor, frequently exploit microvessels as guides for migration. Understanding cell-cell interaction between vascular cells and GBM cells may suggest a new therapeutic direction. We developed physiological 3-D glioma-vascular niche model to investigate this cell-cell interaction using 3-D bioprinting technology. In the model, patient-derived GBM cell cluster was closely located to fluidic vessel. The influence of microenvironmental factors (matrix composition) has been tested in order to provide better control on 3-D cell behavior in future research. The 3D vascular niche platform can be adapted to other biological systems and will be used as a valuable tool to model cell-cell interactions and to control microenvironment in other systems.

Original languageEnglish
Title of host publication2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479983605
DOIs
StatePublished - 2 Jun 2015
Event2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 - Troy, United States
Duration: 17 Apr 201519 Apr 2015

Publication series

Name2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015

Conference

Conference2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
Country/TerritoryUnited States
CityTroy
Period17/04/1519/04/15

Keywords

  • 3D bio-printing
  • cancer-vascular niche
  • glioblastoma
  • glioblastoma multiforme
  • glioma
  • hydrogel
  • tumor invasion
  • vascular niche

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