Generalized seizure activity in an adult rhesus macaque (Macaca mulatta) during ketamine anesthesia and urodynamic studies

Kari L. Christe, Una J. Lee, Marie Josee Lemoy, Leif A. Havton

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We report a case of a generalized seizure in an adult female rhesus macaque (Macaca mulatta) undergoing a urodynamic evaluation while she was anesthetized with continuous-infusion ketamine. The seizure presented with generalized tonic-clonic activity during bladder infusion with saline. The tonic-clonic phase was self-limited and was followed by focal facial twitching, which was interrupted by bolus administration of intravenous diazepam. The ictal event was documented as pressure oscillations during cystometrogram recordings and a period of external urethral sphincter muscle activation, which was detectable by electromyography. An acute decrease in urethral pressure was demonstrated at the end of the generalized seizures. Ketamine anesthesia combined with relatively rapid infusion of saline into the bladder may have contributed to the onset of seizures. In addition, this case highlights the value of having a fast-acting benzodiazepine agent available to stop continuous or residual seizure activity during diagnostic or experimental procedures in anesthetized nonhuman primates.

Original languageEnglish
Pages (from-to)445-447
Number of pages3
JournalComparative Medicine
Volume63
Issue number5
StatePublished - Oct 2013
Externally publishedYes

Fingerprint

Dive into the research topics of 'Generalized seizure activity in an adult rhesus macaque (Macaca mulatta) during ketamine anesthesia and urodynamic studies'. Together they form a unique fingerprint.

Cite this