Generalized Primary Torsion Dystonia

Lawrence Severt, R. Saunders-Pullman

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Dystonia can be classified by etiology - primary or secondary, distribution, age of onset, and site of onset. This chapter discusses primary dystonia where at least one individual in a family, or a sporadic case, has generalized dystonia that affects the legs and trunk. To date, two genes have been identified which are associated with generalized PTD, DYT1 and DYT6, and a third locus, DYT13, has been determined. DYT1 mutations are responsible for much of generalized PTD, but DYT13 is likely causative for only a small portion. As the DYT6 gene was only recently cloned, the relative contribution of this gene to the generalized PTD is not known. However, it is certain that a portion of generalized PTD is due to genetic factors that have yet to be elucidated.

Original languageEnglish
Title of host publicationEncyclopedia of Movement Disorders
PublisherElsevier Inc.
Number of pages8
ISBN (Electronic)9780123741059
ISBN (Print)9780123741011
StatePublished - 1 Jan 2010
Externally publishedYes


  • DYT1
  • DYT13
  • DYT6


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