General and Intensive Care Outcomes for Hospitalized Patients With Solid Organ Transplants With COVID-19

Fiore Mastroianni, Daniel E. Leisman, Grace Fisler, Mangala Narasimhan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Purpose: COVID-19 has been associated with a dysregulated inflammatory response. Patients who have received solid-organ transplants are more susceptible to infections in general due to the use of immunosuppressants. We investigated factors associated with mechanical ventilation and outcomes in solid-organ transplant recipients with COVID-19. Materials and Methods: We conducted a retrospective cohort study of all solid-organ transplant recipients admitted with a diagnosis of COVID-19 in our 23-hospital health system over a 1-month period. Descriptive statistics were used to describe hospital course and laboratory results and bivariate comparisons were performed on variables to determine differences. Results: Twenty-two patients with solid-organ transplants and COVID-19 were identified. Eight patients were admitted to the ICU, of which 7 were intubated. Admission values of CRP (p = 0.045) and N/L ratio (p = 0.047) were associated with the need for mechanical ventilation. Seven patients (32%) died during admission, including 86% (n = 6) of patients who received mechanical ventilation. Conclusions: In solid-organ transplant recipients with COVID-19, initial CRP and N/L ratio were associated with need for mechanical ventilation.

Original languageEnglish
Pages (from-to)494-499
Number of pages6
JournalJournal of Intensive Care Medicine
Volume36
Issue number4
DOIs
StatePublished - Apr 2021

Keywords

  • critical care
  • endotracheal intubation
  • infections
  • respiratory failure

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