Gene transfer to rodent hearts in vivo

Federica del Monte, Kiyotake Ishikawa, Roger J. Hajjar

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations

Abstract

Altering expression of specific genes in rodent models allows the dissection of various pathways involved in various disease states. Advances in gene transfer technologies produced vectors with tissue specificity, various time courses, increasing or knocking down genes in an externally controlled fashion. To achieve this goal, appropriate vector delivery method is essential for successfully conducting experiments. In this chapter, we focus on cardiac gene transfer in rodents that can be employed for delivering both viral and nonviral vectors.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages195-204
Number of pages10
DOIs
StatePublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1521
ISSN (Print)1064-3745

Keywords

  • Adeno virus
  • Adeno-associated virus
  • Gene delivery
  • Modified RNA
  • Mouse
  • Plasmid
  • Rat
  • Small animals

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