Gene therapies for arrhythmias in heart failure

Fadi G. Akar, Roger J. Hajjar

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


In this article, we review recent advances in our understanding of arrhythmia mechanisms in the failing heart. We focus on changes in repolarization, conduction, and intracellular calcium cycling because of their importance to the vast majority of clinical arrhythmias in heart failure. We highlight recent efforts to combat arrhythmias using gene-based approaches that target ion channel, gap junction, and calcium cycling proteins. We further discuss the advantages and limitations associated with individual approaches.

Original languageEnglish
Pages (from-to)1211-1217
Number of pages7
JournalPflugers Archiv European Journal of Physiology
Issue number6
StatePublished - Jun 2014


  • Arrhythmias
  • Conduction
  • Gap junctions
  • Gene therapy
  • Heart failure
  • Repolarization
  • SERCA2a


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