Gene-protein correlation in single cells

Jaclyn J. Renfrow, Adrienne C. Scheck, Neil S. Dhawan, Paul J. Lukac, Hannes Vogel, James P. Chandler, Jeffrey J. Raizer, Griffith R. Harsh, Arnab Chakravarti, Markus Bredel

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


We present a novel methodology combining traditional fluorescent in situ hybridization with an in situ protein detection technology called proximity ligation assay. This method has potential to perform a detailed analysis of the relationship between gene status and corresponding protein expression in cells and tissues. We demonstrate that the fluorescent in situ gene protein assay methodology is capable of resolving gene and protein patterns simultaneously on a cell-by-cell basis.

Original languageEnglish
Pages (from-to)880-885
Number of pages6
Issue number8
StatePublished - Aug 2011
Externally publishedYes


  • Epidermal growth factor receptor
  • Fluorescence in situ gene protein assay
  • Fluorescence in situ hybridization
  • Gene amplification
  • Glioblastoma
  • Proximity ligation assay


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