Gene network analysis of bone marrow mononuclear cells reveals activation of multiple kinase pathways in human systemic lupus erythematosus

Keyphrases

• Systemic Lupus Erythematosus 100%
• Bone Marrow Mononuclear Cells 100%
• Kinase Cascade 100%
• Gene Network Analysis 100%
• Non-Hodgkin Lymphoma 33%
• Insulin 33%
• Systemic Lupus Erythematosus Patient 33%
• Gene Regulators 33%
• Complex Disease 16%
• Immune Response 16%
• Transcription Factor 16%
• Lupus 16%
• Gene Expression Profiling 16%
• Nuclear factor-κB 16%
• Ca2+ 16%
• Translational Regulation 16%
• Post-translational Modification 16%
• Active Disease 16%
• Comparative Analysis 16%
• Subcellular Localization 16%
• Protein-protein Interaction 16%
• Disease Pathogenesis 16%
• Novel Therapies 16%
• Validation Studies 16%
• Genomic Data 16%
• Gene Network 16%
• Bioinformatics Tools 16%
• Lymphoma Patients 16%
• Western Blot Analysis 16%
• Forkhead Box O3 (FOXO3) 16%
• Major Gene 16%
• High Similarity 16%
• Protein Synthesis 16%
• Post-transcriptional Modification 16%
• Ingenuity 16%
• HSPB1 16%
• P38 MAP Kinase 16%
• ERK MAP Kinase 16%
• Lymphoid Malignancies 16%
• Gene Expression Microarray Data 16%
• ERK MAPK 16%
• Splenic B Cells 16%
• Lupus-prone Mice 16%
• JNK MAP Kinase 16%
• Central Gene 16%
• ITGB2 16%
• Functional Gene Network 16%

Biochemistry, Genetics and Molecular Biology

• Kinase 100%
• Phosphotransferase 100%
• Gene Network 100%
• STAT3 60%
• Mouse 40%
• Posttranslational Modification 40%
• Mitogen-Activated Protein Kinase 40%
• Western Blot 20%
• B Cell 20%
• Transcription Factors 20%
• Subcellular Localization 20%
• Protein-Protein Interaction 20%
• Locus Control Region 20%
• Immune Response 20%
• Downregulation 20%
• FOXO3 20%
• Protein Biosynthesis 20%
• Major Gene 20%
• Regulatory Gene 20%
• DNA Microarray 20%
• Post-Transcriptional Modification 20%

Medicine and Dentistry

• Phosphotransferase 100%
• Mononuclear Cell 100%
• Systemic Lupus Erythematosus 100%
• Disease 50%
• Non-Hodgkin Lymphoma 25%
• Kinase 25%
• Lupus Erythematosus 25%
• Mitogen-Activated Protein Kinase 25%
• Transcription Factors 12%
• Calcium Ion 12%
• Immune Response 12%
• Western Blot 12%
• DNA Microarray 12%
• Downregulation 12%
• Mitogen Activated Protein Kinase P38 12%
• Regulator Gene 12%
• Protein Synthesis 12%
• Protein Processing 12%
• STAT3 Protein 12%
• Protein-Protein Interaction 12%
• Lymphoma 12%
• Major Gene 12%
• Phosphorus 32 12%
• Heat Shock Protein 27 12%
• Stress Activated Protein Kinase 12%
• Splenic B Cell 12%