TY - JOUR
T1 - Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosis
AU - Zhan, Fenghuang
AU - Barlogie, Bart
AU - Arzoumanian, Varant
AU - Huang, Yongsheng
AU - Williams, David R.
AU - Hollmig, Klaus
AU - Pineda-Roman, Mauricio
AU - Tricot, Guido
AU - Van Rhee, Frits
AU - Zangari, Maurizio
AU - Dhodapkar, Madhav
AU - Shaughnessy, John D.
PY - 2007/2/15
Y1 - 2007/2/15
N2 - Monoclonal gammopathy of undetermined significance (MGUS) can progress to multiple myeloma (MM). Although these diseases share many of the same genetic features, it is still unclear whether global gene-expression profiling might identify prior genomic signatures that distinguish them. Through significance analysis of microarrays, 52 genes involved in important pathways related to cancer were differentially expressed in the plasma cells of healthy subjects (normal plasma-cell [NPC]; n = 22) and patients with stringently defined MGUS/smoldering MM (n = 24) and symptomatic MM (n = 351) (P < .001). Unsupervised hierarchical clustering of 351 patients with MM, 44 with MGUS (24 + 20), and 16 with MM from MGUS created 2 major cluster branches, one containing 82% of the MGUS patients and the other containing 28% of the MM patients, termed MGUS-like MM (MGUS-L MM). Using the same clustering approach on an independent cohort of 214 patients with MM, 27% were found to be MGUS-L. This molecular signature, despite its association with a lower incidence of complete remission (P < .006), was associated with low-risk clinical and molecular features and superior survival (P < .01). The MGUS-L signature was also seen in plasma cells from 15 of 20 patients surviving more than 10 years after autotransplantation. These data provide insight into the molecular mechanisms of plasma-cell dyscrasias.
AB - Monoclonal gammopathy of undetermined significance (MGUS) can progress to multiple myeloma (MM). Although these diseases share many of the same genetic features, it is still unclear whether global gene-expression profiling might identify prior genomic signatures that distinguish them. Through significance analysis of microarrays, 52 genes involved in important pathways related to cancer were differentially expressed in the plasma cells of healthy subjects (normal plasma-cell [NPC]; n = 22) and patients with stringently defined MGUS/smoldering MM (n = 24) and symptomatic MM (n = 351) (P < .001). Unsupervised hierarchical clustering of 351 patients with MM, 44 with MGUS (24 + 20), and 16 with MM from MGUS created 2 major cluster branches, one containing 82% of the MGUS patients and the other containing 28% of the MM patients, termed MGUS-like MM (MGUS-L MM). Using the same clustering approach on an independent cohort of 214 patients with MM, 27% were found to be MGUS-L. This molecular signature, despite its association with a lower incidence of complete remission (P < .006), was associated with low-risk clinical and molecular features and superior survival (P < .01). The MGUS-L signature was also seen in plasma cells from 15 of 20 patients surviving more than 10 years after autotransplantation. These data provide insight into the molecular mechanisms of plasma-cell dyscrasias.
UR - http://www.scopus.com/inward/record.url?scp=33846894934&partnerID=8YFLogxK
U2 - 10.1182/blood-2006-07-037077
DO - 10.1182/blood-2006-07-037077
M3 - Article
C2 - 17023574
AN - SCOPUS:33846894934
SN - 0006-4971
VL - 109
SP - 1692
EP - 1700
JO - Blood
JF - Blood
IS - 4
ER -