@article{68081d20a5144c488f60e4ee450cd394,
title = "Gene composition of high-yielding influenza vaccine strains obtained by recombination",
abstract = "The genetic composition of 11 high-yielding recombinants of influenza virus was determined by polyacrylamide gel electrophoresis of the 32P-labeled RNAs obtained from the recombinants and their parental viruses. The high-yield recombinants that were selected for potential use as vaccine strains contained the surface hemagglutinin and neuraminidase antigens of the low-yielding parental viruses. The increased growth capacity of the recombinants is associated with the presence of genes derived from the high-yielding laboratory strain A/Puerto Rico/8/34. Although increased growth capacity in these recombinants could not be attributed to specific genes or gene combinations, all of the high-yielding recombinants examined derived the M gene from the A/Puerto Rico/8/34 parent.",
author = "M. Baez and P. Palese and Kilbourne, \{E. D.\}",
note = "Funding Information: Received for publication July 20, 1979, and in revised form October 15, 1979. This work was supported in part by grants no. AI-09304 and AI-11823 from the National Institute of Allergy and Infectious Diseases, grant {"}no. PCM 78-07844 from the National Science Foundation, and grant no. VC-234 from the American Cancer Society. Mr. Baez was supported by a training grant from the National Institutes of Health, and Dr. Palese is the recipient of an Irma T. Hirschi Career Research Award. We thank Barbara A. Pokorny for technical assistance. Please address requests for reprints to Dr. Edwin D. Kilbourne, Department of Microbiology, Mount Sinai Medical Center, 1 Gustave L. Levy Place, New York, New York 10029.",
year = "1980",
doi = "10.1093/infdis/141.3.362",
language = "English",
volume = "141",
pages = "362--365",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "3",
}