TY - JOUR
T1 - Gender-related differences in exercise ventricular function among healthy subjects and patients
AU - Merz, C. Noel Bairey
AU - Moriel, Mady
AU - Rozanski, Alan
AU - Klein, Jacob
AU - Berman, Daniel S.
N1 - Funding Information:
From aThe Cedars-Sinai Medical Center and the University of California at Los Angeles School of Medicine; bthe Shaare Zedek Medical Center, Jerusalem; and Cthe St. Luke's/Roosevelt Hospital Center, Columbia School of Physicians and Surgeons, New York. Supported in part by grants from the Division of Cardiology, Department of Medicine, and the Division of Nuclear Cardiology, Department of Nuclear Medicine, Cedars-Sinai Medical Center; the John D. and Catherine T. MacArthur Foundation; the National Institutes of Health Specialized Center for Research, grant no. 17651; and the National Heart, Lung and Blood Institutes, grant no. 232HL07380. Drs. Moriel and Klein were supported by the Save A Heart Foundation, Los Angeles. Received for publication June 9, 1995; accepted July 27, 1995, Reprint requests: C. Noel Bairey Merz, MD, Division of Cardiology, Cedars-Sinai Medical Center, 444 S. San Vicente Boulevard, Suite 901, Los Angeles, CA 90048. Copyright © 1996 by Mosby-Year Book, Inc. 0002-8703/96/$5.00 + o 4/1/69477
PY - 1996
Y1 - 1996
N2 - Increasing numbers of women are undergoing noninvasive stress testing for coronary artery disease evaluation. Limited information is available regarding the presence, magnitude, and importance of gender-related differences in exercise ventriculography among the heterogeneous population of patients referred for noninvasive stress testing. Patients referred for exercise radionuclide ventriculography between 1979 and 1966 were evaluated, including 175 patients with a low likelihood of coronary artery disease, 59 patients with angiographically normal coronary arteries, and 419 patients with coronary artery disease. Overall, women demonstrated higher resting left ventricular ejection fraction and lower Δ left ventricular ejection fraction response to exercise compared with men. Although left ventricular response to exercise correlated with the underlying severity of coronary artery disease in both women and men, fewer women demonstrated a Δ left ventricular ejection fraction ≥ 5% despite a lower prevalence of multivessel coronary artery disease compared with men. We conclude that gender-related differences in left ventricular response to exercise are present in a wide range of patients referred for testing.
AB - Increasing numbers of women are undergoing noninvasive stress testing for coronary artery disease evaluation. Limited information is available regarding the presence, magnitude, and importance of gender-related differences in exercise ventriculography among the heterogeneous population of patients referred for noninvasive stress testing. Patients referred for exercise radionuclide ventriculography between 1979 and 1966 were evaluated, including 175 patients with a low likelihood of coronary artery disease, 59 patients with angiographically normal coronary arteries, and 419 patients with coronary artery disease. Overall, women demonstrated higher resting left ventricular ejection fraction and lower Δ left ventricular ejection fraction response to exercise compared with men. Although left ventricular response to exercise correlated with the underlying severity of coronary artery disease in both women and men, fewer women demonstrated a Δ left ventricular ejection fraction ≥ 5% despite a lower prevalence of multivessel coronary artery disease compared with men. We conclude that gender-related differences in left ventricular response to exercise are present in a wide range of patients referred for testing.
UR - https://www.scopus.com/pages/publications/15844400287
U2 - 10.1016/S0002-8703(96)90274-4
DO - 10.1016/S0002-8703(96)90274-4
M3 - Article
C2 - 8721642
AN - SCOPUS:15844400287
SN - 0002-8703
VL - 131
SP - 704
EP - 709
JO - American Heart Journal
JF - American Heart Journal
IS - 4
ER -