Gender effect on association between DRD2 polymorphism and substance dependence in a Spanish sample

Jorge López-Castromán, Concepcion Vaquero-Lorenzo, M. Mercedes Perez-Rodriguez, Montserrat Diaz-Hernandez, Jose Fernandez-Piqueras, Jeronimo Saiz-Ruiz, Enrique Baca-Garcia

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Our aim was to examine a possible association between substance dependence and the TaqIA polymorphism of the D2 dopamine receptor (DRD2), a single nucleotide polymorphism (SNP) located at the 3′ UTR region of the DRD2 gene. A case-control design stratified by gender was used to analyze the genotypes of this SNP in a sample of 125 substance-dependent patients according to DSM-IV and 203 blood donors recruited as controls in two general city hospitals in Madrid, Spain. Genomic DNA from peripheral blood samples was amplified through PCR to identify the variants of the SNP in the DRD2 gene. Analyses performed with Chi2 tests revealed that the A1 allele (A1/A1 and A1/A2 genotypes) of the Taq 1A SNP of the DRD2 gene was significantly associated with substance dependence in males, but not in the whole sample. Male patients had significantly higher rates of the A1-containing genotypes than male controls. The finding of an association between substance dependence and the DRD2 gene TaqIA SNP only in males suggests the existence of gender-specific differences in the genetic underpinnings of substance dependence.

Original languageEnglish
Pages (from-to)210-212
Number of pages3
JournalDrug and Alcohol Dependence
Volume101
Issue number3
DOIs
StatePublished - 1 May 2009

Keywords

  • Dopamine
  • Gender
  • Genetics
  • Substance dependence

Fingerprint

Dive into the research topics of 'Gender effect on association between DRD2 polymorphism and substance dependence in a Spanish sample'. Together they form a unique fingerprint.

Cite this