Gender differences in prodynorphin but not proenkephalin mRNA expression in the striatum of adolescent rats exposed to prenatal cocaine

Annelyn Torres-Reveron; Yasmin L. Hurd; Diana L. Dow-Edwards

doi:10.1016/j.neulet.2007.05.001

Gender differences in prodynorphin but not proenkephalin mRNA expression in the striatum of adolescent rats exposed to prenatal cocaine

Annelyn Torres-Reveron, Yasmin L. Hurd, Diana L. Dow-Edwards

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The objective of this study was to determine if prenatal cocaine affects the levels of prodynorphin and proenkephalin mRNA in male and female adolescent rats. Pregnant dams received cocaine or vehicle from gestational days 8-22 and upon delivery, the pups were fostered. At postnatal days 42-44, pups were killed and brains removed and frozen. Sections of striatum and nucleus accumbens were processed for prodynorphin and proenkephalin mRNA expression. Prenatal cocaine did not affect the expression of proenkephalin mRNA, but males showed higher expression than females. However, prodynorphin mRNA was lower in female rats exposed to cocaine compared to controls. Prenatal cocaine appears to have unique effects on neuropeptides during adolescence.

Original language	English
Pages (from-to)	213-217
Number of pages	5
Journal	Neuroscience Letters
Volume	421
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2007.05.001
State	Published - 29 Jun 2007
Externally published	Yes

Keywords

Dopamine-opiate interactions
Drug abuse
Molecular changes
Pregnancy
Prenatal cocaine

Access to Document

10.1016/j.neulet.2007.05.001

Cite this

@article{dcf1775bb72b49fb983ec319739af682,

title = "Gender differences in prodynorphin but not proenkephalin mRNA expression in the striatum of adolescent rats exposed to prenatal cocaine",

abstract = "The objective of this study was to determine if prenatal cocaine affects the levels of prodynorphin and proenkephalin mRNA in male and female adolescent rats. Pregnant dams received cocaine or vehicle from gestational days 8-22 and upon delivery, the pups were fostered. At postnatal days 42-44, pups were killed and brains removed and frozen. Sections of striatum and nucleus accumbens were processed for prodynorphin and proenkephalin mRNA expression. Prenatal cocaine did not affect the expression of proenkephalin mRNA, but males showed higher expression than females. However, prodynorphin mRNA was lower in female rats exposed to cocaine compared to controls. Prenatal cocaine appears to have unique effects on neuropeptides during adolescence.",

keywords = "Dopamine-opiate interactions, Drug abuse, Molecular changes, Pregnancy, Prenatal cocaine",

author = "Annelyn Torres-Reveron and Hurd, {Yasmin L.} and Dow-Edwards, {Diana L.}",

note = "Funding Information: Technical support from April Jackson, Lucille Grullon and Stacy Stephenson for prenatal treatment is greatly appreciated. Statistical analysis was done by Jeremy Weedon, PhD from the Scientific Computing Center at SUNY Health Science Center, Brooklyn, NY. Supported by: NIDA-10990 to DDE, Swedish Science Council 11252 to YLH and American Psychological Association Neuroscience Development Fellowship to A.T.R.",

year = "2007",

month = jun,

day = "29",

doi = "10.1016/j.neulet.2007.05.001",

language = "English",

volume = "421",

pages = "213--217",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Gender differences in prodynorphin but not proenkephalin mRNA expression in the striatum of adolescent rats exposed to prenatal cocaine

AU - Torres-Reveron, Annelyn

AU - Hurd, Yasmin L.

AU - Dow-Edwards, Diana L.

N1 - Funding Information: Technical support from April Jackson, Lucille Grullon and Stacy Stephenson for prenatal treatment is greatly appreciated. Statistical analysis was done by Jeremy Weedon, PhD from the Scientific Computing Center at SUNY Health Science Center, Brooklyn, NY. Supported by: NIDA-10990 to DDE, Swedish Science Council 11252 to YLH and American Psychological Association Neuroscience Development Fellowship to A.T.R.

PY - 2007/6/29

Y1 - 2007/6/29

N2 - The objective of this study was to determine if prenatal cocaine affects the levels of prodynorphin and proenkephalin mRNA in male and female adolescent rats. Pregnant dams received cocaine or vehicle from gestational days 8-22 and upon delivery, the pups were fostered. At postnatal days 42-44, pups were killed and brains removed and frozen. Sections of striatum and nucleus accumbens were processed for prodynorphin and proenkephalin mRNA expression. Prenatal cocaine did not affect the expression of proenkephalin mRNA, but males showed higher expression than females. However, prodynorphin mRNA was lower in female rats exposed to cocaine compared to controls. Prenatal cocaine appears to have unique effects on neuropeptides during adolescence.

AB - The objective of this study was to determine if prenatal cocaine affects the levels of prodynorphin and proenkephalin mRNA in male and female adolescent rats. Pregnant dams received cocaine or vehicle from gestational days 8-22 and upon delivery, the pups were fostered. At postnatal days 42-44, pups were killed and brains removed and frozen. Sections of striatum and nucleus accumbens were processed for prodynorphin and proenkephalin mRNA expression. Prenatal cocaine did not affect the expression of proenkephalin mRNA, but males showed higher expression than females. However, prodynorphin mRNA was lower in female rats exposed to cocaine compared to controls. Prenatal cocaine appears to have unique effects on neuropeptides during adolescence.

KW - Dopamine-opiate interactions

KW - Drug abuse

KW - Molecular changes

KW - Pregnancy

KW - Prenatal cocaine

UR - http://www.scopus.com/inward/record.url?scp=34250663081&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2007.05.001

DO - 10.1016/j.neulet.2007.05.001

M3 - Article

C2 - 17574751

AN - SCOPUS:34250663081

SN - 0304-3940

VL - 421

SP - 213

EP - 217

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Gender differences in prodynorphin but not proenkephalin mRNA expression in the striatum of adolescent rats exposed to prenatal cocaine

Abstract

Keywords

Access to Document

Fingerprint

Cite this