Gender differences in cholesterol-lowering medication prescribing in peripheral artery disease

Mary M. McDermott, Philip Greenland, George Reed, Kathleen M. Mazor, Philip A. Merriam, Rex Graff, Huimin Tao, Sherry Pagoto, Larry Manheim, Melina R. Kibbe, Ira S. Ockene

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Among 320 patients with lower extremity peripheral artery disease (PAD) and low-density lipoprotein-cholesterol (LDL-C) levels > 70 mg/dl, we determined whether male sex, higher education, and greater self-efficacy for willingness to request therapy from one's physician were associated with increases in LDL-C-lowering medication and achievement of an LDL-C level < 70 mg/dl at 1-year follow-up. Participants were enrolled in a randomized controlled clinical trial to determine whether a telephone counseling intervention can help PAD patients achieve an LDL-C level < 70 mg/dl, compared to usual care and attention control conditions, respectively. Adjusting for age, race, comorbidities, PAD severity, and other covariates, male sex (odds ratio = 3.33, 95% confidence interval = 1.64 to 6.77, p = 0.001) was associated with a higher likelihood of adding cholesterol-lowering medication during follow-up, but was not associated with achieving an LDL-C < 70 mg/dl (odds ratio = 1.09, 95% confidence interval = 0.55 to 2.18). No associations of education level or self-efficacy with study outcomes were identified. In conclusion, male PAD patients with baseline LDL-C levels ≥ 70 mg/dl were more likely to intensify LDL-C-lowering medication during 1-year follow-up than female PAD patients. Despite greater increases in LDL-C-lowering medication among female PAD patients, there was no difference in the degree of LDL-C lowering during the study between men and women with PAD. Clinical Trial Registration-URL:

Original languageEnglish
Pages (from-to)428-435
Number of pages8
JournalVascular Medicine
Issue number6
StatePublished - Dec 2011
Externally publishedYes


  • intermittent claudication
  • peripheral artery disease
  • prevention
  • quality of care


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