Gemcitabine associated retinopathy and nephropathy

Alan T. Sheyman; Kenneth J. Wald; Patricia J. Pahk; K. Bailey Freund

doi:10.1097/ICB.0000000000000015

Gemcitabine associated retinopathy and nephropathy

Alan T. Sheyman, Kenneth J. Wald, Patricia J. Pahk, K. Bailey Freund

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Abstract

Purpose: To report a case of presumed gemcitabine-induced retinopathy and nephropathy. Methods: Case Report. Retrospective chart review. Results: A 64-year-old woman with a recent diagnosis of metastatic cholangiocarcinoma presented with progressive visual loss and renal failure shortly after the initiation of a chemotherapy regimen which included gemcitabine. Clinical examination and fluorescein angiography showed findings of severe retinal ischemia. Conclusion: Although gemcitabine chemotherapy has been reported to cause a Purtscherlike retinopathy, we propose in our patient a gemcitabine-induced vasculopathy that lead to significant retinal and renal ischemia.

Original language	English
Pages (from-to)	107-109
Number of pages	3
Journal	Retinal Cases and Brief Reports
Volume	8
Issue number	2
DOIs	https://doi.org/10.1097/ICB.0000000000000015
State	Published - 2014

Keywords

Gemcitabine retinopathy

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10.1097/ICB.0000000000000015

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title = "Gemcitabine associated retinopathy and nephropathy",

abstract = "Purpose: To report a case of presumed gemcitabine-induced retinopathy and nephropathy. Methods: Case Report. Retrospective chart review. Results: A 64-year-old woman with a recent diagnosis of metastatic cholangiocarcinoma presented with progressive visual loss and renal failure shortly after the initiation of a chemotherapy regimen which included gemcitabine. Clinical examination and fluorescein angiography showed findings of severe retinal ischemia. Conclusion: Although gemcitabine chemotherapy has been reported to cause a Purtscherlike retinopathy, we propose in our patient a gemcitabine-induced vasculopathy that lead to significant retinal and renal ischemia.",

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AU - Sheyman, Alan T.

AU - Wald, Kenneth J.

AU - Pahk, Patricia J.

AU - Freund, K. Bailey

PY - 2014

Y1 - 2014

N2 - Purpose: To report a case of presumed gemcitabine-induced retinopathy and nephropathy. Methods: Case Report. Retrospective chart review. Results: A 64-year-old woman with a recent diagnosis of metastatic cholangiocarcinoma presented with progressive visual loss and renal failure shortly after the initiation of a chemotherapy regimen which included gemcitabine. Clinical examination and fluorescein angiography showed findings of severe retinal ischemia. Conclusion: Although gemcitabine chemotherapy has been reported to cause a Purtscherlike retinopathy, we propose in our patient a gemcitabine-induced vasculopathy that lead to significant retinal and renal ischemia.

AB - Purpose: To report a case of presumed gemcitabine-induced retinopathy and nephropathy. Methods: Case Report. Retrospective chart review. Results: A 64-year-old woman with a recent diagnosis of metastatic cholangiocarcinoma presented with progressive visual loss and renal failure shortly after the initiation of a chemotherapy regimen which included gemcitabine. Clinical examination and fluorescein angiography showed findings of severe retinal ischemia. Conclusion: Although gemcitabine chemotherapy has been reported to cause a Purtscherlike retinopathy, we propose in our patient a gemcitabine-induced vasculopathy that lead to significant retinal and renal ischemia.

KW - Gemcitabine retinopathy

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JO - Retinal Cases and Brief Reports

JF - Retinal Cases and Brief Reports

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ER -

Gemcitabine associated retinopathy and nephropathy

Abstract

Keywords

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