Gaucher disease: Assessment of skeletal involvement and therapeutic responses to enzyme replacement

G. Hermann; G. M. Pastores; I. F. Abdelwahab; A. M. Lorberboym

doi:10.1007/s002560050313

Gaucher disease: Assessment of skeletal involvement and therapeutic responses to enzyme replacement

G. Hermann
, G. M. Pastores
, I. F. Abdelwahab
, A. M. Lorberboym

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Review article › peer-review

64 Scopus citations

Abstract

The clinical, pathological and radiological manifestations of type 1 Gaucher disease and the role of imaging techniques such as CT, MRI and sulfur-colloid scintigraphy in the management of these patients is discussed. MRI appears to be the most valuable imaging technique for evaluating bone marrow involvement and detecting disease activity. MRI is also useful in assessing therapeutic responses to enzyme replacement therapy.

Original language	English
Pages (from-to)	687-696
Number of pages	10
Journal	Skeletal Radiology
Volume	26
Issue number	12
DOIs	https://doi.org/10.1007/s002560050313
State	Published - Dec 1997

Keywords

Gaucher disease type 1
Imaging CT
MRI, Gaucher disease
Skeletal changes, Gaucher disease

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10.1007/s002560050313

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title = "Gaucher disease: Assessment of skeletal involvement and therapeutic responses to enzyme replacement",

abstract = "The clinical, pathological and radiological manifestations of type 1 Gaucher disease and the role of imaging techniques such as CT, MRI and sulfur-colloid scintigraphy in the management of these patients is discussed. MRI appears to be the most valuable imaging technique for evaluating bone marrow involvement and detecting disease activity. MRI is also useful in assessing therapeutic responses to enzyme replacement therapy.",

keywords = "Gaucher disease type 1, Imaging CT, MRI, Gaucher disease, Skeletal changes, Gaucher disease",

author = "G. Hermann and Pastores, \{G. M.\} and Abdelwahab, \{I. F.\} and Lorberboym, \{A. M.\}",

note = "Funding Information: Acknowledgements This work was supported in part by the National Institutes of Health, including a grant (5 M01 RR00071) for the Mount Sinai General Clinical Research Center from the National Center for Research Resources and a grant (5 P30 HD28822) for the Mount Sinai Child Health Research Center (MSCHRC). G.M.P. was a Pediatric Young Investigator Awardee (MSCHRC); currently, he is the recipient of a Minority Clinical Associate Physician Award (5M01-RR00071) from the National Institutes of Health.",

year = "1997",

month = dec,

doi = "10.1007/s002560050313",

language = "English",

volume = "26",

pages = "687--696",

journal = "Skeletal Radiology",

issn = "0364-2348",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "12",

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TY - JOUR

T1 - Gaucher disease

T2 - Assessment of skeletal involvement and therapeutic responses to enzyme replacement

AU - Hermann, G.

AU - Pastores, G. M.

AU - Abdelwahab, I. F.

AU - Lorberboym, A. M.

N1 - Funding Information: Acknowledgements This work was supported in part by the National Institutes of Health, including a grant (5 M01 RR00071) for the Mount Sinai General Clinical Research Center from the National Center for Research Resources and a grant (5 P30 HD28822) for the Mount Sinai Child Health Research Center (MSCHRC). G.M.P. was a Pediatric Young Investigator Awardee (MSCHRC); currently, he is the recipient of a Minority Clinical Associate Physician Award (5M01-RR00071) from the National Institutes of Health.

PY - 1997/12

Y1 - 1997/12

N2 - The clinical, pathological and radiological manifestations of type 1 Gaucher disease and the role of imaging techniques such as CT, MRI and sulfur-colloid scintigraphy in the management of these patients is discussed. MRI appears to be the most valuable imaging technique for evaluating bone marrow involvement and detecting disease activity. MRI is also useful in assessing therapeutic responses to enzyme replacement therapy.

AB - The clinical, pathological and radiological manifestations of type 1 Gaucher disease and the role of imaging techniques such as CT, MRI and sulfur-colloid scintigraphy in the management of these patients is discussed. MRI appears to be the most valuable imaging technique for evaluating bone marrow involvement and detecting disease activity. MRI is also useful in assessing therapeutic responses to enzyme replacement therapy.

KW - Gaucher disease type 1

KW - Imaging CT

KW - MRI, Gaucher disease

KW - Skeletal changes, Gaucher disease

UR - https://www.scopus.com/pages/publications/0031440938

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DO - 10.1007/s002560050313

M3 - Review article

C2 - 9453101

AN - SCOPUS:0031440938

SN - 0364-2348

VL - 26

SP - 687

EP - 696

JO - Skeletal Radiology

JF - Skeletal Radiology

IS - 12

ER -

Gaucher disease: Assessment of skeletal involvement and therapeutic responses to enzyme replacement

Abstract

Keywords

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