GATE simulations for small animal SPECT/PET using voxelized phantoms and rotating-head detectors

Nikolas Sakellios, Jose Luis Rubio, Nicolas Karakatsanis, George Kontaxakis, George Loudos, Andres Santos, Konstantina Nikita, Stan Majewski

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

19 Scopus citations

Abstract

GATE (Geant4 Application for Tomographic Emission) simulation toolkit has become a well validated toolkit for the simulation of SPECT and PET systems. A very important feature of GATE is that it allows modelling of time-dependent phenomena. In addition, complex voxelized object such as realistic anthropomorphic or small animal phantoms can be used as emission sources. In this work two small field of view scanners have been evaluated experimentally, modelled in GATE and mice studies have been simulated using MOBY mouse phantom. Two scanners have been simulated: The first one is a mouse sized gamma camera (field of view is 5×10cm) that is based on two Hamamatsu H8500 PSPMTs, a NaI pixelized scintillator and a tungsten collimator with hexagonal parallel holes. The system has been modelled in GATE and good agreement has been found between simulation and experimental results. MOBY mouse has been introduced as a voxelized source and planar and tomography simulations were carried out. The second small animal PET scanner has four heads which are equipped with a H8500 PSPMTs and a pixelated LYSO scintillator. System's geometry has been modelled in GATE. The results of both systems simulation and comparison between simulation and experimental data are presented. In addition, mouse bone scans were simulated both for SPECT and PET and tomographic image are derived. The presented methodology is aimed to provide all necessary tools in order to perform optimized simulations of small animal emission tomography scans.

Original languageEnglish
Title of host publication2006 IEEE Nuclear Science Symposium - Conference Record
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2000-2003
Number of pages4
ISBN (Print)1424405610, 9781424405619
DOIs
StatePublished - 2006
Externally publishedYes
Event2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD - San Diego, CA, United States
Duration: 29 Oct 20064 Nov 2006

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume4
ISSN (Print)1095-7863

Conference

Conference2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
Country/TerritoryUnited States
CitySan Diego, CA
Period29/10/064/11/06

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