GATA2 finds its macrophage niche

In this issue of Blood,Hsu et al¹ and Dickinson et al ² independently report the presence of mutations in the region of GATA2 encoding the carboxy-terminal zincfinger domain of the protein in a rare genetic disease associated with reduced production of marrow-derived immune cells susceptible to development of myelodysplastic syndrome and acute myeloid leukemia.