Gastrointestinal changes after bariatric surgery

I. Quercia, R. Dutia, D. P. Kotler, S. Belsley, B. Laferrère

Research output: Contribution to journalReview articlepeer-review

82 Scopus citations

Abstract

Severe obesity is a preeminent health care problem that impacts overall health and survival. The most effective treatment for severe obesity is bariatric surgery, an intervention that not only maintains long-term weight loss but also is associated with improvement or remission of several comorbidies including type 2 diabetes mellitus. Some weight loss surgeries modify the gastrointestinal anatomy and physiology, including the secretions and actions of gut peptides. This review describes how bariatric surgery alters the patterns of gastrointestinal motility, nutrient digestion and absorption, gut peptide release, bile acids and the gut microflora, and how these changes alter energy homeostasis and glucose metabolism.

Original languageEnglish
Pages (from-to)87-94
Number of pages8
JournalDiabetes and Metabolism
Volume40
Issue number2
DOIs
StatePublished - Apr 2014
Externally publishedYes

Keywords

  • Bariatric surgery
  • Diabetes
  • Gastric bypass
  • Gut peptides
  • Obesity

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