Gastric or coeliac vagotomy decreases drinking after peripheral angiotensin II

C. Jerome; G. P. Smith

doi:10.1016/0031-9384(82)90278-5

Gastric or coeliac vagotomy decreases drinking after peripheral angiotensin II

C. Jerome, G. P. Smith

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

After bilateral subdiaphragmatic vagotomy, rats drank later and less in response to peripherally administered angiotensin II [13]. We attempted to localize this deficit neurologically by performing selective gastric, hepatic or coeliac vagotomies. The drinking responses of such selectively lesioned rats to 0.1 and 1.0 mg·kg^-1 angiotensin II (SC) were compared to those of total bilateral vagotomized rats and sham vagotomized rats. Gastric or coeliac vagotomy produced drinking deficits that were similar to those produced by total abdominal vagotomy, but hepatic vagotomy did not. These results demonstrate the importance of abdominal vagal mechanisms in the drinking response to circulating angiotensin II.

Original language	English
Pages (from-to)	533-536
Number of pages	4
Journal	Physiology and Behavior
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/0031-9384(82)90278-5
State	Published - Sep 1982
Externally published	Yes

Keywords

Angiotensin II
Coeliac vagotomy
Drinking deficits
Extracellular thirst
Gastric vagotomy
Hepatic vagotomy
Hypertonic saline
Intracellular thirst
Vagotomy

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10.1016/0031-9384(82)90278-5

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title = "Gastric or coeliac vagotomy decreases drinking after peripheral angiotensin II",

abstract = "After bilateral subdiaphragmatic vagotomy, rats drank later and less in response to peripherally administered angiotensin II [13]. We attempted to localize this deficit neurologically by performing selective gastric, hepatic or coeliac vagotomies. The drinking responses of such selectively lesioned rats to 0.1 and 1.0 mg·kg-1 angiotensin II (SC) were compared to those of total bilateral vagotomized rats and sham vagotomized rats. Gastric or coeliac vagotomy produced drinking deficits that were similar to those produced by total abdominal vagotomy, but hepatic vagotomy did not. These results demonstrate the importance of abdominal vagal mechanisms in the drinking response to circulating angiotensin II.",

keywords = "Angiotensin II, Coeliac vagotomy, Drinking deficits, Extracellular thirst, Gastric vagotomy, Hepatic vagotomy, Hypertonic saline, Intracellular thirst, Vagotomy",

author = "C. Jerome and Smith, {G. P.}",

note = "Funding Information: We thank Dr. K. Simansky for his critique of this manuscript and Mrs. M. Jacobsen, Mrs. N. Conte, and Mrs. J. Magnetti for typing the manuscript. G. P. S. was supported by Career Development Award MH00149 and the research was supported by MH 15455.",

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doi = "10.1016/0031-9384(82)90278-5",

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journal = "Physiology and Behavior",

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T1 - Gastric or coeliac vagotomy decreases drinking after peripheral angiotensin II

AU - Jerome, C.

AU - Smith, G. P.

N1 - Funding Information: We thank Dr. K. Simansky for his critique of this manuscript and Mrs. M. Jacobsen, Mrs. N. Conte, and Mrs. J. Magnetti for typing the manuscript. G. P. S. was supported by Career Development Award MH00149 and the research was supported by MH 15455.

PY - 1982/9

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N2 - After bilateral subdiaphragmatic vagotomy, rats drank later and less in response to peripherally administered angiotensin II [13]. We attempted to localize this deficit neurologically by performing selective gastric, hepatic or coeliac vagotomies. The drinking responses of such selectively lesioned rats to 0.1 and 1.0 mg·kg-1 angiotensin II (SC) were compared to those of total bilateral vagotomized rats and sham vagotomized rats. Gastric or coeliac vagotomy produced drinking deficits that were similar to those produced by total abdominal vagotomy, but hepatic vagotomy did not. These results demonstrate the importance of abdominal vagal mechanisms in the drinking response to circulating angiotensin II.

AB - After bilateral subdiaphragmatic vagotomy, rats drank later and less in response to peripherally administered angiotensin II [13]. We attempted to localize this deficit neurologically by performing selective gastric, hepatic or coeliac vagotomies. The drinking responses of such selectively lesioned rats to 0.1 and 1.0 mg·kg-1 angiotensin II (SC) were compared to those of total bilateral vagotomized rats and sham vagotomized rats. Gastric or coeliac vagotomy produced drinking deficits that were similar to those produced by total abdominal vagotomy, but hepatic vagotomy did not. These results demonstrate the importance of abdominal vagal mechanisms in the drinking response to circulating angiotensin II.

KW - Angiotensin II

KW - Coeliac vagotomy

KW - Drinking deficits

KW - Extracellular thirst

KW - Gastric vagotomy

KW - Hepatic vagotomy

KW - Hypertonic saline

KW - Intracellular thirst

KW - Vagotomy

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ER -

Gastric or coeliac vagotomy decreases drinking after peripheral angiotensin II

Abstract

Keywords

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