Gardner-diamond syndrome

Gardner-Diamond syndrome, which also is known as autoerythrocyte sensitization disorder, is a rare syndrome of inflammatory, edematous papules that evolve into painful ecchymoses on the trunk and lower legs after a period of stress with no prior history of trauma. This syndrome usually occurs in women with a history of psychiatric disorders, the most common one being depression. Although the exact mechanism of injury is not well understood, it is hypothesized that these patients have autoantibodies to phosphatidylserine, which is a phospholipid membrane component in erythrocytes. Treatment for this disorder includes symptomatic therapies and psychotropic medications to treat the underlying psychiatric disorder.