Gamma-aminobutyric acid (GABA) in the CSF of schizophrenic patients before and after neuroleptic treatment

D. Lichtshtein; J. Dobkin; R. P. Ebstein; J. Biederman; R. Rimon; R. H. Belmaker

doi:10.1192/bjp.132.2.145

Gamma-aminobutyric acid (GABA) in the CSF of schizophrenic patients before and after neuroleptic treatment

D. Lichtshtein, J. Dobkin, R. P. Ebstein, J. Biederman, R. Rimon, R. H. Belmaker

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Abstract

Gamma aminobutyric acid (GABA) levels in the CSF were measured in 9 normal individuals, 17 drug-free schizophrenic patients and 10 of these same schizophrenic patients after neuroleptic treatment. There was no significant difference between CSF level of GABA in the control group compared to those in schizophrenic patients; however, 6 of the 7 lowest GABA levels were from schizophrenic patients. There was a significant decline of 12 percent in mean GABA levels in the CSF after a mean of two months of neuroleptic treatment.

Original language	English
Pages (from-to)	145-148
Number of pages	4
Journal	Unknown Journal
Volume	132
Issue number	2
DOIs	https://doi.org/10.1192/bjp.132.2.145
State	Published - 1978
Externally published	Yes

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abstract = "Gamma aminobutyric acid (GABA) levels in the CSF were measured in 9 normal individuals, 17 drug-free schizophrenic patients and 10 of these same schizophrenic patients after neuroleptic treatment. There was no significant difference between CSF level of GABA in the control group compared to those in schizophrenic patients; however, 6 of the 7 lowest GABA levels were from schizophrenic patients. There was a significant decline of 12 percent in mean GABA levels in the CSF after a mean of two months of neuroleptic treatment.",

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AU - Lichtshtein, D.

AU - Dobkin, J.

AU - Ebstein, R. P.

AU - Biederman, J.

AU - Rimon, R.

AU - Belmaker, R. H.

PY - 1978

Y1 - 1978

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AB - Gamma aminobutyric acid (GABA) levels in the CSF were measured in 9 normal individuals, 17 drug-free schizophrenic patients and 10 of these same schizophrenic patients after neuroleptic treatment. There was no significant difference between CSF level of GABA in the control group compared to those in schizophrenic patients; however, 6 of the 7 lowest GABA levels were from schizophrenic patients. There was a significant decline of 12 percent in mean GABA levels in the CSF after a mean of two months of neuroleptic treatment.

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Gamma-aminobutyric acid (GABA) in the CSF of schizophrenic patients before and after neuroleptic treatment

Abstract

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