Galanin stimulates rat pituitary growth hormone secretion in vitro

Steven M. Gabriel, Carol M. Milbury, James A. Nathanson, Joseph B. Martin

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


The effect of galanin on growth hormone (GH) secretion was investigated in monolayer cultures of rat anterior pituitary cells. Galanin caused a gradual increase in GH concentrations into the culture medium that was maximal at 90 minutes and sustained after 180 minutes. The ED50 for galanin-stimulated GH secretion was approximately 200nM compared to an ED50 for rat GH-releasing factor (rGRF)-stimulated GH secretion of 10pM. Galanin and rGRF were additive in increasing GH release into the incubation medium. These data indicate that porcine-derived galanin has a direct effect on pituitary GH secretion in vitro.

Original languageEnglish
Pages (from-to)1981-1986
Number of pages6
JournalLife Sciences
Issue number20
StatePublished - 1988
Externally publishedYes


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