Galanin can attenuate opiate reinforcement and withdrawal

Marina R. Picciotto; Jessica J. Hawes; Darlene H. Brunzell; Venetia Zachariou

doi:10.1016/j.npep.2004.12.001

Galanin can attenuate opiate reinforcement and withdrawal

Marina R. Picciotto, Jessica J. Hawes, Darlene H. Brunzell, Venetia Zachariou

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Galanin and its receptors are expressed in brain areas associated with opiate reinforcement and withdrawal. An emerging body of data suggests that galanin can attenuate the neurochemical, physiological and behavioral signs of opiate reinforcement and withdrawal. Experiments in transgenic mice overexpressing galanin and knockout mice lacking the peptide support a role for endogenous galanin in modulating the actions of opiates on brain regions associated with reinforcement and withdrawal. These studies suggest that galanin receptor agonists could be useful therapeutic agents to combat opiate addiction. Further, genetic variation in the genes encoding galanin and its receptors could be associated with altered susceptibility to opiate dependence.

Original language	English
Pages (from-to)	313-315
Number of pages	3
Journal	Neuropeptides
Volume	39
Issue number	3
DOIs	https://doi.org/10.1016/j.npep.2004.12.001
State	Published - Jun 2005
Externally published	Yes

Keywords

CREB
GalRl
Galanin receptors
Knockout mice
Transgenic mice

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10.1016/j.npep.2004.12.001

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@article{68e02451fe214061917711b0de256e3f,

title = "Galanin can attenuate opiate reinforcement and withdrawal",

abstract = "Galanin and its receptors are expressed in brain areas associated with opiate reinforcement and withdrawal. An emerging body of data suggests that galanin can attenuate the neurochemical, physiological and behavioral signs of opiate reinforcement and withdrawal. Experiments in transgenic mice overexpressing galanin and knockout mice lacking the peptide support a role for endogenous galanin in modulating the actions of opiates on brain regions associated with reinforcement and withdrawal. These studies suggest that galanin receptor agonists could be useful therapeutic agents to combat opiate addiction. Further, genetic variation in the genes encoding galanin and its receptors could be associated with altered susceptibility to opiate dependence.",

keywords = "CREB, GalRl, Galanin receptors, Knockout mice, Transgenic mice",

author = "Picciotto, {Marina R.} and Hawes, {Jessica J.} and Brunzell, {Darlene H.} and Venetia Zachariou",

note = "Funding Information: This work was supported by Grants DA15425 and DA00436 from the National Institutes of Health. ",

year = "2005",

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doi = "10.1016/j.npep.2004.12.001",

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pages = "313--315",

journal = "Neuropeptides",

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publisher = "Churchill Livingstone",

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T1 - Galanin can attenuate opiate reinforcement and withdrawal

AU - Picciotto, Marina R.

AU - Hawes, Jessica J.

AU - Brunzell, Darlene H.

AU - Zachariou, Venetia

N1 - Funding Information: This work was supported by Grants DA15425 and DA00436 from the National Institutes of Health.

PY - 2005/6

Y1 - 2005/6

N2 - Galanin and its receptors are expressed in brain areas associated with opiate reinforcement and withdrawal. An emerging body of data suggests that galanin can attenuate the neurochemical, physiological and behavioral signs of opiate reinforcement and withdrawal. Experiments in transgenic mice overexpressing galanin and knockout mice lacking the peptide support a role for endogenous galanin in modulating the actions of opiates on brain regions associated with reinforcement and withdrawal. These studies suggest that galanin receptor agonists could be useful therapeutic agents to combat opiate addiction. Further, genetic variation in the genes encoding galanin and its receptors could be associated with altered susceptibility to opiate dependence.

AB - Galanin and its receptors are expressed in brain areas associated with opiate reinforcement and withdrawal. An emerging body of data suggests that galanin can attenuate the neurochemical, physiological and behavioral signs of opiate reinforcement and withdrawal. Experiments in transgenic mice overexpressing galanin and knockout mice lacking the peptide support a role for endogenous galanin in modulating the actions of opiates on brain regions associated with reinforcement and withdrawal. These studies suggest that galanin receptor agonists could be useful therapeutic agents to combat opiate addiction. Further, genetic variation in the genes encoding galanin and its receptors could be associated with altered susceptibility to opiate dependence.

KW - CREB

KW - GalRl

KW - Galanin receptors

KW - Knockout mice

KW - Transgenic mice

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DO - 10.1016/j.npep.2004.12.001

M3 - Article

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AN - SCOPUS:20444398171

SN - 0143-4179

VL - 39

SP - 313

EP - 315

JO - Neuropeptides

JF - Neuropeptides

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ER -

Galanin can attenuate opiate reinforcement and withdrawal

Abstract

Keywords

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