Galactorrhea and Parkinson-like syndrome: An adverse effect of α-methyldopa

Rama A. Vaidya; Ashok B. Vaidya; Melvin H. Van Woert; Nathan G. Kase

doi:10.1016/0026-0495(70)90031-4

Galactorrhea and Parkinson-like syndrome: An adverse effect of α-methyldopa

Rama A. Vaidya, Ashok B. Vaidya, Melvin H. Van Woert, Nathan G. Kase

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14 Scopus citations

Abstract

Methyldopa induced galactorrhea and a Parkinson-like syndrome in a 15-year-old girl with chronic glomerulonephritis. On discontinuation of the drug, the adverse effects disappeared and did not recur. Dopamine and/or norepinephrine deficiency induced by methyldopa is proposed as a probable central mechanism for these adverse effects.

Original language	English
Pages (from-to)	1068-1070
Number of pages	3
Journal	Metabolism: Clinical and Experimental
Volume	19
Issue number	12
DOIs	https://doi.org/10.1016/0026-0495(70)90031-4
State	Published - Dec 1970
Externally published	Yes

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title = "Galactorrhea and Parkinson-like syndrome: An adverse effect of α-methyldopa",

abstract = "Methyldopa induced galactorrhea and a Parkinson-like syndrome in a 15-year-old girl with chronic glomerulonephritis. On discontinuation of the drug, the adverse effects disappeared and did not recur. Dopamine and/or norepinephrine deficiency induced by methyldopa is proposed as a probable central mechanism for these adverse effects.",

author = "Vaidya, {Rama A.} and Vaidya, {Ashok B.} and {Van Woert}, {Melvin H.} and Kase, {Nathan G.}",

year = "1970",

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T2 - An adverse effect of α-methyldopa

AU - Vaidya, Rama A.

AU - Vaidya, Ashok B.

AU - Van Woert, Melvin H.

AU - Kase, Nathan G.

PY - 1970/12

Y1 - 1970/12

N2 - Methyldopa induced galactorrhea and a Parkinson-like syndrome in a 15-year-old girl with chronic glomerulonephritis. On discontinuation of the drug, the adverse effects disappeared and did not recur. Dopamine and/or norepinephrine deficiency induced by methyldopa is proposed as a probable central mechanism for these adverse effects.

AB - Methyldopa induced galactorrhea and a Parkinson-like syndrome in a 15-year-old girl with chronic glomerulonephritis. On discontinuation of the drug, the adverse effects disappeared and did not recur. Dopamine and/or norepinephrine deficiency induced by methyldopa is proposed as a probable central mechanism for these adverse effects.

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U2 - 10.1016/0026-0495(70)90031-4

DO - 10.1016/0026-0495(70)90031-4

M3 - Article

C2 - 4923681

AN - SCOPUS:0014911429

SN - 0026-0495

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EP - 1070

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

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ER -

Galactorrhea and Parkinson-like syndrome: An adverse effect of α-methyldopa

Abstract

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