Gabapentin Toxicity in Children Manifesting as Behavioral Changes

Steven M. Wolf; Shlomo Shinnar; Harriet Kang; Karen Ballaban Gil; Solomon L. Moshé

doi:10.1111/j.1528-1157.1995.tb01063.x

Gabapentin Toxicity in Children Manifesting as Behavioral Changes

Steven M. Wolf
, Shlomo Shinnar
, Harriet Kang
, Karen Ballaban Gil
, Solomon L. Moshé

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

Summary: Pediatric experience with gabapentin (GBP), a new antiepileptic drug (AED), is limited. We describe 3 learning disabled children, 1 aged 7 years and 2 aged 10 years, with intractable partial seizures who developed severe behavioral problems while receiving modest doses of GBP. The children became hyperactive and had explosive outbursts consisting of aggressive and oppositional behavior. The behavioral problems were sufficiently severe to require discontinuation of GBP despite moderately improved seizure control.

Original language	English
Pages (from-to)	1203-1205
Number of pages	3
Journal	Epilepsia
Volume	36
Issue number	12
DOIs	https://doi.org/10.1111/j.1528-1157.1995.tb01063.x
State	Published - Dec 1995
Externally published	Yes

Keywords

Anticonvulsants
Children's behavioral events
Gabapentin

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10.1111/j.1528-1157.1995.tb01063.x

Cite this

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abstract = "Summary: Pediatric experience with gabapentin (GBP), a new antiepileptic drug (AED), is limited. We describe 3 learning disabled children, 1 aged 7 years and 2 aged 10 years, with intractable partial seizures who developed severe behavioral problems while receiving modest doses of GBP. The children became hyperactive and had explosive outbursts consisting of aggressive and oppositional behavior. The behavioral problems were sufficiently severe to require discontinuation of GBP despite moderately improved seizure control.",

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AU - Shinnar, Shlomo

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AU - Gil, Karen Ballaban

AU - Moshé, Solomon L.

PY - 1995/12

Y1 - 1995/12

N2 - Summary: Pediatric experience with gabapentin (GBP), a new antiepileptic drug (AED), is limited. We describe 3 learning disabled children, 1 aged 7 years and 2 aged 10 years, with intractable partial seizures who developed severe behavioral problems while receiving modest doses of GBP. The children became hyperactive and had explosive outbursts consisting of aggressive and oppositional behavior. The behavioral problems were sufficiently severe to require discontinuation of GBP despite moderately improved seizure control.

AB - Summary: Pediatric experience with gabapentin (GBP), a new antiepileptic drug (AED), is limited. We describe 3 learning disabled children, 1 aged 7 years and 2 aged 10 years, with intractable partial seizures who developed severe behavioral problems while receiving modest doses of GBP. The children became hyperactive and had explosive outbursts consisting of aggressive and oppositional behavior. The behavioral problems were sufficiently severe to require discontinuation of GBP despite moderately improved seizure control.

KW - Anticonvulsants

KW - Children's behavioral events

KW - Gabapentin

UR - https://www.scopus.com/pages/publications/0028850583

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Gabapentin Toxicity in Children Manifesting as Behavioral Changes

Abstract

Keywords

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