GABAergic synapses: Their plasticity and role in sensory cortex

Trevor C. Griffen, Arianna Maffei

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


The mammalian neocortex is composed of a variety of cell types organized in a highly interconnected circuit. GABAergic neurons account for only about 20% of cortical neurons. However, they show widespread connectivity and a high degree of diversity in morphology, location, electrophysiological properties and gene expression. In addition, distinct populations of inhibitory neurons have different sensory response properties, capacities for plasticity and sensitivities to changes in sensory experience. In this review we summarize experimental evidence regarding the properties of GABAergic neurons in primary sensory cortex. We will discuss how distinct GABAergic neurons and different forms of GABAergic inhibitory plasticity may contribute to shaping sensory cortical circuit activity and function.

Original languageEnglish
Article number91
JournalFrontiers in Cellular Neuroscience
Issue numberMAR
StatePublished - 26 Mar 2014
Externally publishedYes


  • GABA
  • Inhibition
  • Inhibitory neurons
  • Sensory cortex
  • Synaptic plasticity


Dive into the research topics of 'GABAergic synapses: Their plasticity and role in sensory cortex'. Together they form a unique fingerprint.

Cite this