GABAergic synapses: Their plasticity and role in sensory cortex

Trevor C. Griffen; Arianna Maffei

doi:10.3389/fncel.2014.00091

GABAergic synapses: Their plasticity and role in sensory cortex

Trevor C. Griffen, Arianna Maffei

Research output: Contribution to journal › Review article › peer-review

58 Scopus citations

Abstract

The mammalian neocortex is composed of a variety of cell types organized in a highly interconnected circuit. GABAergic neurons account for only about 20% of cortical neurons. However, they show widespread connectivity and a high degree of diversity in morphology, location, electrophysiological properties and gene expression. In addition, distinct populations of inhibitory neurons have different sensory response properties, capacities for plasticity and sensitivities to changes in sensory experience. In this review we summarize experimental evidence regarding the properties of GABAergic neurons in primary sensory cortex. We will discuss how distinct GABAergic neurons and different forms of GABAergic inhibitory plasticity may contribute to shaping sensory cortical circuit activity and function.

Original language	English
Article number	91
Journal	Frontiers in Cellular Neuroscience
Volume	8
Issue number	MAR
DOIs	https://doi.org/10.3389/fncel.2014.00091
State	Published - 26 Mar 2014
Externally published	Yes

Keywords

GABA
Inhibition
Inhibitory neurons
Sensory cortex
Synaptic plasticity

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10.3389/fncel.2014.00091

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AB - The mammalian neocortex is composed of a variety of cell types organized in a highly interconnected circuit. GABAergic neurons account for only about 20% of cortical neurons. However, they show widespread connectivity and a high degree of diversity in morphology, location, electrophysiological properties and gene expression. In addition, distinct populations of inhibitory neurons have different sensory response properties, capacities for plasticity and sensitivities to changes in sensory experience. In this review we summarize experimental evidence regarding the properties of GABAergic neurons in primary sensory cortex. We will discuss how distinct GABAergic neurons and different forms of GABAergic inhibitory plasticity may contribute to shaping sensory cortical circuit activity and function.

KW - GABA

KW - Inhibition

KW - Inhibitory neurons

KW - Sensory cortex

KW - Synaptic plasticity

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JO - Frontiers in Cellular Neuroscience

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ER -

GABAergic synapses: Their plasticity and role in sensory cortex

Abstract

Keywords

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