G protein-coupled receptor heterocomplexes in neuropsychiatric disorders

José L. Moreno, Terrell Holloway, Javier González-Maeso

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

26 Scopus citations

Abstract

G protein-coupled receptors (or GPCRs) represent the largest family of membrane proteins in the human genome and are the target of approximately half of all therapeutic drugs. GPCRs contain a conserved structure of seven transmembrane domains. Their amino terminus is located extracellularly, whereas the carboxy terminus extends into the cytoplasm. Accumulating evidence suggests that GPCRs exist and function as monomeric entities. Nevertheless, more recent findings indicate that GPCRs can also form dimers or even higher order oligomers. The differential pharmacological and signaling properties of GPCR heteromeric complexes hint that their physiological effects may be different as compared to those obtained in tissue cultures that express a particular GPCR. In this chapter, we review current data on the role of GPCR heteromerization in receptor signaling, as well as its potential implication in neuropsychiatric disorders such as schizophrenia, depression, and Parkinson's disease.

Original languageEnglish
Title of host publicationOligomerization in Health and Disease
PublisherElsevier B.V.
Pages187-205
Number of pages19
ISBN (Print)9780123869319
DOIs
StatePublished - 2013

Publication series

NameProgress in Molecular Biology and Translational Science
Volume117
ISSN (Print)1877-1173

Keywords

  • Depression
  • G protein-coupled receptors
  • Parkinson's disease
  • Psychiatry
  • Receptor dimerization
  • Receptor heteromerization
  • Schizophrenia

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