G-protein β3 subunit 825 C/T polymorphism is associated with weight gain during pregnancy

Victor Dishy, Simi Gupta, Ruth Landau, Hong Guang Xie, Richard B. Kim, Richard M. Smiley, Daniel W. Byrne, Alastair J.J. Wood, C. Michael Stein

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

A common polymorphism (C825T) of the gene encoding the G-protein β3 subunit has been associated with obesity. We examined the hypothesis that this polymorphism affected weight gain during pregnancy. Two hundred and ninety-four women with uncomplicated term deliveries of singleton pregnancies were genotyped. Women homozygous for the T allele (TT) gained significantly more weight than women carrying the C allele (CC and CT groups) (P = 0.006) and had a significantly higher pre-pregnancy body mass index (P = 0.02). The C825T polymorphism of the G-protein β3 subunit gene, known to be associated with obesity, is a determinant of weight gain during pregnancy.

Original languageEnglish
Pages (from-to)241-242
Number of pages2
JournalPharmacogenetics
Volume13
Issue number4
DOIs
StatePublished - Apr 2003
Externally publishedYes

Keywords

  • G-protein
  • Polymorphism
  • Pregnancy
  • Weight gain

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