Abstract
The 825C/T polymorphism of the G-protein beta-3 subunit (GPB3) results in increased activity of pertussis toxin-sensitive G-proteins in vitro, and has been associated with obesity and hypertension in humans. The 825T polymorphism has recently been associated with low birth weight and maternal weight retention after pregnancy. Genomic DNA was analyzed for the C/T polymorphism in 436 women with normal pregnancy (243 Hispanic (H), 141 Caucasian (C, 52 African-American (AA)), and 76 (52 H, 14 AA, 10 C) with pre-eclampsia (PET). Healthy women homozygous for the TT polymorphism gained significantly more weight than CC homozygotes (17.4±1 kg, mean±SEM vs 14.8±0.5, p=0.03). There was no association between C/T genotype and PET (all p>0.05, Table). Hispanic African American Caucasian Allele Control PET Control PET Control PET 48% 52% 33% 25% 62% 85% T 52% 48% 67% 75% 38% 15%.
Original language | English |
---|---|
Pages (from-to) | P75 |
Journal | Clinical Pharmacology and Therapeutics |
Volume | 69 |
Issue number | 2 |
State | Published - 2001 |
Externally published | Yes |