G-protein β-3 subunit 825C/T polymorphism is associated with weight gain in pregnancy but not with preeclampsia

S. Gupta, V. Dishy, H. G. Xie, R. Landau, R. M. Smiley, A. J.J. Wood, R. B. Kim, C. M. Stein

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The 825C/T polymorphism of the G-protein beta-3 subunit (GPB3) results in increased activity of pertussis toxin-sensitive G-proteins in vitro, and has been associated with obesity and hypertension in humans. The 825T polymorphism has recently been associated with low birth weight and maternal weight retention after pregnancy. Genomic DNA was analyzed for the C/T polymorphism in 436 women with normal pregnancy (243 Hispanic (H), 141 Caucasian (C, 52 African-American (AA)), and 76 (52 H, 14 AA, 10 C) with pre-eclampsia (PET). Healthy women homozygous for the TT polymorphism gained significantly more weight than CC homozygotes (17.4±1 kg, mean±SEM vs 14.8±0.5, p=0.03). There was no association between C/T genotype and PET (all p>0.05, Table). Hispanic African American Caucasian Allele Control PET Control PET Control PET 48% 52% 33% 25% 62% 85% T 52% 48% 67% 75% 38% 15%.

Original languageEnglish
Pages (from-to)P75
JournalClinical Pharmacology and Therapeutics
Volume69
Issue number2
StatePublished - 2001
Externally publishedYes

Fingerprint

Dive into the research topics of 'G-protein β-3 subunit 825C/T polymorphism is associated with weight gain in pregnancy but not with preeclampsia'. Together they form a unique fingerprint.

Cite this