FusionPub, a therapeutic landscape of human fusion genes

Himansu Kumar; Abayomi Adegunlehin; Zikang Chen; Pora Kim

doi:10.1093/bib/bbaf145

FusionPub, a therapeutic landscape of human fusion genes

Himansu Kumar, Abayomi Adegunlehin, Zikang Chen, Pora Kim

Research output: Contribution to journal › Article › peer-review

Abstract

To advance the development of fusion protein–targeting therapeutics, it is crucial to understand how patients with fusion oncoproteins have been treated and what small molecules have been studied. To fill this gap, we developed FusionPub, a knowledgebase of the therapeutic landscape of human fusion genes. We searched PubMed abstracts for 107K human fusion genes with 14K drugs. We also searched PubMed abstracts for 18K human fusion proteins, considering all gene synonyms of individual partner genes with 14K drugs. After manual curation, we found 17 342 records from 9623 PubMed abstracts. For these fusion genes and drugs, we provide a summary sentence of their relationship using the generative AI, details of the drugs, clinical trial records, common drug records from patient treatment history, etc. FusionPub will be a valuable and unique resource providing knowledge of the development of fusion gene targeting therapeutics.

Original language	English
Article number	bbaf145
Journal	Briefings in Bioinformatics
Volume	26
Issue number	2
DOIs	https://doi.org/10.1093/bib/bbaf145
State	Published - 1 Mar 2025
Externally published	Yes

Keywords

ClinicalTrials.gov
drug
fusion gene
PubMed
therapeutics

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AU - Chen, Zikang

AU - Kim, Pora

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FusionPub, a therapeutic landscape of human fusion genes

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