@article{bb6e96e2a4364ddc8a036e72f566938d,
title = "Further evidence for direct pro-resorptive actions of FSH",
abstract = "We confirm that FSH stimulates osteoclast formation, function and survival to enhance bone resorption. It does so via the activation of a pertussis toxin-sensitive Gi-coupled FSH receptor that we and others have identified on murine and human osteoclast precursors and mature osteoclasts. FSH additionally enhances the production of several osteoclastogenic cytokines, importantly TNFα, likely within the bone marrow microenvironment, to augment its pro-resorptive action. FSH levels in humans rise before estrogen falls, and this hormonal change coincides with the most rapid rates of bone loss. On the basis of accumulating evidence, we reaffirm that FSH contributes to the rapid peri-menopausal and early post-menopausal bone loss, which might thus be amenable to FSH blockade.",
keywords = "Bone loss, FSH, Gonadotropin, Osteoclast, Osteoporosis",
author = "Li Sun and Zhiyuan Zhang and Zhu, {Ling Ling} and Yuanzhen Peng and Xuan Liu and Jianhua Li and Manasi Agrawal and Robinson, {Lisa J.} and Jameel Iqbal and Blair, {Harry C.} and Mone Zaidi",
note = "Funding Information: This work was supported by the National Institute on Aging ( AG23176 to M.Z.). M.Z., L.S., and H.C.B. also acknowledge the National Institutes of Health for grant support ( DK70526 , DK80490 , AR053976 , AR055208 , and AR053566 . H.C.B. and J.I. also acknowledges the Department of Veterans Affairs and the American Federation for Aging Research, respectively. M.Z. is a named inventor of a pending patent application related to osteoclastic bone resorption filed by Mount Sinai School of Medicine. In the event the pending or issued patent is licensed, M.Z. will be entitled to a share of the proceeds.",
year = "2010",
month = mar,
day = "26",
doi = "10.1016/j.bbrc.2010.02.113",
language = "English",
volume = "394",
pages = "6--11",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Elsevier B.V.",
number = "1",
}