Further evidence for direct pro-resorptive actions of FSH

Li Sun, Zhiyuan Zhang, Ling Ling Zhu, Yuanzhen Peng, Xuan Liu, Jianhua Li, Manasi Agrawal, Lisa J. Robinson, Jameel Iqbal, Harry C. Blair, Mone Zaidi

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

We confirm that FSH stimulates osteoclast formation, function and survival to enhance bone resorption. It does so via the activation of a pertussis toxin-sensitive Gi-coupled FSH receptor that we and others have identified on murine and human osteoclast precursors and mature osteoclasts. FSH additionally enhances the production of several osteoclastogenic cytokines, importantly TNFα, likely within the bone marrow microenvironment, to augment its pro-resorptive action. FSH levels in humans rise before estrogen falls, and this hormonal change coincides with the most rapid rates of bone loss. On the basis of accumulating evidence, we reaffirm that FSH contributes to the rapid peri-menopausal and early post-menopausal bone loss, which might thus be amenable to FSH blockade.

Original languageEnglish
Pages (from-to)6-11
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume394
Issue number1
DOIs
StatePublished - 26 Mar 2010

Keywords

  • Bone loss
  • FSH
  • Gonadotropin
  • Osteoclast
  • Osteoporosis

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