Further evidence for altered cerebellar neuronal integrity in schizophrenia

Gabriele Ende, Petra Hubrich, Sigrid Walter, Wolfgang Weber-Fahr, Nina Kämmerer, Dieter F. Braus, Fritz A. Henn

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Objective: The authors' goal was to investigate the distribution of metabolites and voxel composition in the pons and three cerebellar subregions and compare metabolite integral values and differences in voxel composition between patients with schizophrenia and healthy subjects. Method: Proton magnetic resonance spectroscopic imaging was used to study the cerebellum and pons of 14 patients with schizophrenia and 14 healthy comparison subjects. Results: The voxel composition was not significantly different between the groups, but the patients with schizophrenia had significantly lower N-acetylaspartate levels in the cerebellar cortex and vermis. Conclusions: The lower integral value of N-acetylaspartate in the cerebellar cortex and the vermis of patients with schizophrenia supports the theory of a dysfunctional corticocerebellar-thalamic-cortical circuit in schizophrenia.

Original languageEnglish
Pages (from-to)790-792
Number of pages3
JournalAmerican Journal of Psychiatry
Volume162
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

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