@article{79a72902a2a0408fb62cafa1bac110a2,
title = "Further characterization of the putative glycolipid receptor for mif: Role of fucose associated with an acidic glycolipid",
abstract = "Water soluble glycolipids were extracted from guinea pig macrophages. These glycolipids, when incubated with macrophages, augment the cells' response to migration inhibitory factor. The glycolipids were fractionated by diethylaminoethyl-Sephadex ion exchange chromatography into neutral and acidic fractions. Only the acidic glycolipid fraction was able to enhance the responsiveness of macrophages to migration inhibitory factor. Additional studies indicate that the enhancing activity of these glycolipid preparations can be abrogated by the removal of terminal fucose residues with α-L-fucosidase. The possibility that fucose functions as an essential component of a macrophage glycolipid receptor for migration inhibitory factor is discussed.",
author = "Higgins, {Terry J.} and Liu, {David Y.} and Remold, {Heinz G.} and David, {John R.}",
note = "Funding Information: *This work was supported in part by USPHS Grants AI-12110, AI-07685 and AI-10921, and a Grant-in-Aid from the American Heart Association. TJH current address is Department of Microbiology, John Curtin School of Medical Research, The Australian National University, Box 334, Canberra City, A.C.T. 2601, Australia. DYL, recipient of a National Cancer Institute Fellowship #5 CA-05753. HGR, recipient of an Established Investigatorship from the American Heart Assoc. Please address correspondence to Dr. David Y. Liu, Seeley G. Mudd Bldg., Fifth Floor, 250 Longwood Ave., Boston, MA 02115 *Abbreviations: MIF, migration inhibitory factor; Gal(NANA)-Glc-Cer; GalNAc, N-acetylgalactosaminyl; Gal, N-acetylneuraminic acid; Glc, glucosyl; Cer, ceramide; diethylaminoethyl; HBSS, Hanks' balanced salt solution; medium; C:M, chloroform:methanol; PMNL, polymorphonuclear ethylene diaminetetraacetic GSL, glycosphingolipids; chromatography.",
year = "1980",
month = apr,
day = "29",
doi = "10.1016/0006-291X(80)90625-7",
language = "English",
volume = "93",
pages = "1259--1265",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "4",
}