Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis

Irina Leonardi, Sudarshan Paramsothy, Itai Doron, Alexa Semon, Nadeem O. Kaakoush, Jose C. Clemente, Jeremiah J. Faith, Thomas J. Borody, Hazel M. Mitchell, Jean Frederic Colombel, Michael A. Kamm, Iliyan D. Iliev

Research output: Contribution to journalArticlepeer-review

113 Scopus citations

Abstract

Leonardi et al. show that high burdens of intestinal Candida prior to FMT are associated with an increased responsiveness to FMT in ulcerative colitis patients in a multi-center, double-blind, randomized, placebo-controlled trial. These results suggest that FMT might reduce Candida abundance and restrict pro-inflammatory immunity during intestinal inflammation.

Original languageEnglish
Pages (from-to)823-829.e3
JournalCell Host and Microbe
Volume27
Issue number5
DOIs
StatePublished - 13 May 2020

Keywords

  • Candida
  • fecal microbiota transplantation
  • gut fungi
  • mycobiota
  • ulcerative colitis

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