@article{231c38bdb0304e05803abd884a8436db,
title = "Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis",
abstract = "Leonardi et al. show that high burdens of intestinal Candida prior to FMT are associated with an increased responsiveness to FMT in ulcerative colitis patients in a multi-center, double-blind, randomized, placebo-controlled trial. These results suggest that FMT might reduce Candida abundance and restrict pro-inflammatory immunity during intestinal inflammation.",
keywords = "Candida, fecal microbiota transplantation, gut fungi, mycobiota, ulcerative colitis",
author = "Irina Leonardi and Sudarshan Paramsothy and Itai Doron and Alexa Semon and Kaakoush, {Nadeem O.} and Clemente, {Jose C.} and Faith, {Jeremiah J.} and Borody, {Thomas J.} and Mitchell, {Hazel M.} and Colombel, {Jean Frederic} and Kamm, {Michael A.} and Iliev, {Iliyan D.}",
note = "Funding Information: Research in the Iliev laboratory is supported by the US National Institutes of Health (DK113136, DK121977 and AI137157), the Crohn's and Colitis Foundation Senior Research Award, the Helmsley Charitable Trust, the Irma T. Hirschl Career Scientist Award, pilot funding from the Center for Advanced Digestive Care (CADC), and the JRI for research in IBD. J.F.C. is supported by the Cutting-Edge Therapies for Ulcerative Colitis grant; H.M.M. is supported by a Litwin IBD Pioneer Award from Crohn's and Colitis Foundation; I.L. is supported by fellowships from the Crohn's and Colitis Foundation. Conceptualization: I.D.I. I.L.; Investigation: I.L. S.P. I.D. A.S. N.O.K. J.C. J.J.F. T.J.B. H.M.M. J.F.C. M.A.K. and I.D.I.; Writing – Original Draft: I.D.I. I.L.; Writing – Revisions: I.D.I. I.L.; Supervision: I.D.I.; Funding Acquisition: I.D.I. T.J.B. has a pecuniary interest in the Centre for Digestive Disease and holds patents in FMT treatment. The other authors declare no competing interests related to this study. Funding Information: Research in the Iliev laboratory is supported by the US National Institutes of Health ( DK113136 , DK121977 and AI137157 ), the Crohn{\textquoteright}s and Colitis Foundation Senior Research Award, the Helmsley Charitable Trust , the Irma T. Hirschl Career Scientist Award, pilot funding from the Center for Advanced Digestive Care (CADC), and the JRI for research in IBD. J.F.C. is supported by the Cutting-Edge Therapies for Ulcerative Colitis grant; H.M.M. is supported by a Litwin IBD Pioneer Award from Crohn{\textquoteright}s and Colitis Foundation; I.L. is supported by fellowships from the Crohn{\textquoteright}s and Colitis Foundation. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = may,
day = "13",
doi = "10.1016/j.chom.2020.03.006",
language = "English",
volume = "27",
pages = "823--829.e3",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "5",
}